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Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence

Background. Lactose malabsorption (LM) is a frequent clinical problem associated with several digestive and extra-digestive diseases. The aim of this manuscript was to clarify the real clinical impact of LM on these disorders. Methods. A literature search for digestive and extra-digestive disorders...

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Autores principales: Usai-Satta, Paolo, Lai, Mariantonia, Oppia, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838180/
https://www.ncbi.nlm.nih.gov/pubmed/35276940
http://dx.doi.org/10.3390/nu14030584
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author Usai-Satta, Paolo
Lai, Mariantonia
Oppia, Francesco
author_facet Usai-Satta, Paolo
Lai, Mariantonia
Oppia, Francesco
author_sort Usai-Satta, Paolo
collection PubMed
description Background. Lactose malabsorption (LM) is a frequent clinical problem associated with several digestive and extra-digestive diseases. The aim of this manuscript was to clarify the real clinical impact of LM on these disorders. Methods. A literature search for digestive and extra-digestive disorders related to LM was carried out using PubMed, Medline and Cochrane. Results. A transient lactase deficiency is present in celiac disease (CD) on a normal diet. The persistence of symptoms in CD on a gluten-free diet may be instead, in part, attributed to a primary LM. Similar circumstances are present in inflammatory bowel diseases (IBD), in which LM can be responsible for a part of persistent symptoms in IBD on clinical remission. LM and irritable bowel syndrome (IBS) are instead independent conditions. On the other hand, a lactose-restricted diet may be useful for some IBS patients. A reduced lactose intake can lead to low bone mass and limited risk of fragility fractures. Finally, the absorption of levothyroxine could be conditioned by LM. Conclusions. LM can be responsible for persistent symptoms in CD and IBD. The association with IBS seems to be casual. Bone mass and levothyroxine absorption can be affected by LM.
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spelling pubmed-88381802022-02-13 Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence Usai-Satta, Paolo Lai, Mariantonia Oppia, Francesco Nutrients Communication Background. Lactose malabsorption (LM) is a frequent clinical problem associated with several digestive and extra-digestive diseases. The aim of this manuscript was to clarify the real clinical impact of LM on these disorders. Methods. A literature search for digestive and extra-digestive disorders related to LM was carried out using PubMed, Medline and Cochrane. Results. A transient lactase deficiency is present in celiac disease (CD) on a normal diet. The persistence of symptoms in CD on a gluten-free diet may be instead, in part, attributed to a primary LM. Similar circumstances are present in inflammatory bowel diseases (IBD), in which LM can be responsible for a part of persistent symptoms in IBD on clinical remission. LM and irritable bowel syndrome (IBS) are instead independent conditions. On the other hand, a lactose-restricted diet may be useful for some IBS patients. A reduced lactose intake can lead to low bone mass and limited risk of fragility fractures. Finally, the absorption of levothyroxine could be conditioned by LM. Conclusions. LM can be responsible for persistent symptoms in CD and IBD. The association with IBS seems to be casual. Bone mass and levothyroxine absorption can be affected by LM. MDPI 2022-01-28 /pmc/articles/PMC8838180/ /pubmed/35276940 http://dx.doi.org/10.3390/nu14030584 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Usai-Satta, Paolo
Lai, Mariantonia
Oppia, Francesco
Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence
title Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence
title_full Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence
title_fullStr Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence
title_full_unstemmed Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence
title_short Lactose Malabsorption and Presumed Related Disorders: A Review of Current Evidence
title_sort lactose malabsorption and presumed related disorders: a review of current evidence
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838180/
https://www.ncbi.nlm.nih.gov/pubmed/35276940
http://dx.doi.org/10.3390/nu14030584
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