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Recently Discovered Secondary Metabolites from Streptomyces Species

The Streptomyces genus has been a rich source of bioactive natural products, medicinal chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the genus is capable of making some 150,000 more bioactive compounds than all Streptomyces secondary metabolites reported t...

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Autores principales: Lacey, Heather J., Rutledge, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838263/
https://www.ncbi.nlm.nih.gov/pubmed/35164153
http://dx.doi.org/10.3390/molecules27030887
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author Lacey, Heather J.
Rutledge, Peter J.
author_facet Lacey, Heather J.
Rutledge, Peter J.
author_sort Lacey, Heather J.
collection PubMed
description The Streptomyces genus has been a rich source of bioactive natural products, medicinal chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the genus is capable of making some 150,000 more bioactive compounds than all Streptomyces secondary metabolites reported to date. Researchers around the world continue to explore this enormous potential using a range of strategies including modification of culture conditions, bioinformatics and genome mining, heterologous expression, and other approaches to cryptic biosynthetic gene cluster activation. Our survey of the recent literature, with a particular focus on the year 2020, brings together more than 70 novel secondary metabolites from Streptomyces species, which are discussed in this review. This diverse array includes cyclic and linear peptides, peptide derivatives, polyketides, terpenoids, polyaromatics, macrocycles, and furans, the isolation, chemical structures, and bioactivity of which are appraised. The discovery of these many different compounds demonstrates the continued potential of Streptomyces as a source of new and interesting natural products and contributes further important pieces to the mostly unfinished puzzle of Earth’s myriad microbes and their multifaceted chemical output.
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spelling pubmed-88382632022-02-13 Recently Discovered Secondary Metabolites from Streptomyces Species Lacey, Heather J. Rutledge, Peter J. Molecules Review The Streptomyces genus has been a rich source of bioactive natural products, medicinal chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the genus is capable of making some 150,000 more bioactive compounds than all Streptomyces secondary metabolites reported to date. Researchers around the world continue to explore this enormous potential using a range of strategies including modification of culture conditions, bioinformatics and genome mining, heterologous expression, and other approaches to cryptic biosynthetic gene cluster activation. Our survey of the recent literature, with a particular focus on the year 2020, brings together more than 70 novel secondary metabolites from Streptomyces species, which are discussed in this review. This diverse array includes cyclic and linear peptides, peptide derivatives, polyketides, terpenoids, polyaromatics, macrocycles, and furans, the isolation, chemical structures, and bioactivity of which are appraised. The discovery of these many different compounds demonstrates the continued potential of Streptomyces as a source of new and interesting natural products and contributes further important pieces to the mostly unfinished puzzle of Earth’s myriad microbes and their multifaceted chemical output. MDPI 2022-01-28 /pmc/articles/PMC8838263/ /pubmed/35164153 http://dx.doi.org/10.3390/molecules27030887 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lacey, Heather J.
Rutledge, Peter J.
Recently Discovered Secondary Metabolites from Streptomyces Species
title Recently Discovered Secondary Metabolites from Streptomyces Species
title_full Recently Discovered Secondary Metabolites from Streptomyces Species
title_fullStr Recently Discovered Secondary Metabolites from Streptomyces Species
title_full_unstemmed Recently Discovered Secondary Metabolites from Streptomyces Species
title_short Recently Discovered Secondary Metabolites from Streptomyces Species
title_sort recently discovered secondary metabolites from streptomyces species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838263/
https://www.ncbi.nlm.nih.gov/pubmed/35164153
http://dx.doi.org/10.3390/molecules27030887
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