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Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice
Constipation is a symptom that is widely found in the world’s population. Various dietary supplementations are used to relieve and prevent constipation. Seaweed is widely used for its health benefits. In this study, we aimed to investigate the effects of Sargassum plagiophyllum extract (SPE) on func...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838385/ https://www.ncbi.nlm.nih.gov/pubmed/35276855 http://dx.doi.org/10.3390/nu14030496 |
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author | Khuituan, Pissared Huipao, Nawiya Jeanmard, Nilobon Thantongsakul, Sitthiwach Promjun, Warittha Chuthong, Suwarat Tipbunjong, Chittipong Peerakietkhajorn, Saranya |
author_facet | Khuituan, Pissared Huipao, Nawiya Jeanmard, Nilobon Thantongsakul, Sitthiwach Promjun, Warittha Chuthong, Suwarat Tipbunjong, Chittipong Peerakietkhajorn, Saranya |
author_sort | Khuituan, Pissared |
collection | PubMed |
description | Constipation is a symptom that is widely found in the world’s population. Various dietary supplementations are used to relieve and prevent constipation. Seaweed is widely used for its health benefits. In this study, we aimed to investigate the effects of Sargassum plagiophyllum extract (SPE) on functions of the gastrointestinal tract and gut microbiota. The results show that SPE pretreatment increased the frequency of gut contraction, leading to reduce gut transit time. SPE pretreatment also significantly increased the secretion of Cl(−) and reduced Na(+) absorption, increasing fecal water content in constipated mice (p < 0.05). In addition, the Bifidobacteria population in cecal contents was significantly higher in constipated mice pretreated with 500 mg/kg SPE for 14 days than in untreated constipated mice (p < 0.05). Our findings suggest that SPE can prevent constipation in loperamide-induced mice. This study may be useful for the development of human food supplements from S. plagiophyllum, which prevent constipation. |
format | Online Article Text |
id | pubmed-8838385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88383852022-02-13 Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice Khuituan, Pissared Huipao, Nawiya Jeanmard, Nilobon Thantongsakul, Sitthiwach Promjun, Warittha Chuthong, Suwarat Tipbunjong, Chittipong Peerakietkhajorn, Saranya Nutrients Article Constipation is a symptom that is widely found in the world’s population. Various dietary supplementations are used to relieve and prevent constipation. Seaweed is widely used for its health benefits. In this study, we aimed to investigate the effects of Sargassum plagiophyllum extract (SPE) on functions of the gastrointestinal tract and gut microbiota. The results show that SPE pretreatment increased the frequency of gut contraction, leading to reduce gut transit time. SPE pretreatment also significantly increased the secretion of Cl(−) and reduced Na(+) absorption, increasing fecal water content in constipated mice (p < 0.05). In addition, the Bifidobacteria population in cecal contents was significantly higher in constipated mice pretreated with 500 mg/kg SPE for 14 days than in untreated constipated mice (p < 0.05). Our findings suggest that SPE can prevent constipation in loperamide-induced mice. This study may be useful for the development of human food supplements from S. plagiophyllum, which prevent constipation. MDPI 2022-01-24 /pmc/articles/PMC8838385/ /pubmed/35276855 http://dx.doi.org/10.3390/nu14030496 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Khuituan, Pissared Huipao, Nawiya Jeanmard, Nilobon Thantongsakul, Sitthiwach Promjun, Warittha Chuthong, Suwarat Tipbunjong, Chittipong Peerakietkhajorn, Saranya Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice |
title | Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice |
title_full | Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice |
title_fullStr | Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice |
title_full_unstemmed | Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice |
title_short | Sargassum plagiophyllum Extract Enhances Colonic Functions and Modulates Gut Microbiota in Constipated Mice |
title_sort | sargassum plagiophyllum extract enhances colonic functions and modulates gut microbiota in constipated mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838385/ https://www.ncbi.nlm.nih.gov/pubmed/35276855 http://dx.doi.org/10.3390/nu14030496 |
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