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Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES

Trace element accumulation varies in different human tissues. Distribution of several elements was found to be disrupted in the case of excessive alcohol consumption, causing negative effects and exacerbation of pathological processes in the liver. In this study, we analyzed the levels and interacti...

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Autores principales: Baj, Jacek, Teresiński, Grzegorz, Forma, Alicja, Flieger, Michał, Proch, Jędrzej, Niedzielski, Przemysław, Grochowski, Cezary, Blicharska, Eliza, Buszewicz, Grzegorz, Bogucki, Jacek, Majerek, Dariusz, Karakuła, Kaja, Czeczelewski, Marcin, Flieger, Jolanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838438/
https://www.ncbi.nlm.nih.gov/pubmed/35276905
http://dx.doi.org/10.3390/nu14030546
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author Baj, Jacek
Teresiński, Grzegorz
Forma, Alicja
Flieger, Michał
Proch, Jędrzej
Niedzielski, Przemysław
Grochowski, Cezary
Blicharska, Eliza
Buszewicz, Grzegorz
Bogucki, Jacek
Majerek, Dariusz
Karakuła, Kaja
Czeczelewski, Marcin
Flieger, Jolanta
author_facet Baj, Jacek
Teresiński, Grzegorz
Forma, Alicja
Flieger, Michał
Proch, Jędrzej
Niedzielski, Przemysław
Grochowski, Cezary
Blicharska, Eliza
Buszewicz, Grzegorz
Bogucki, Jacek
Majerek, Dariusz
Karakuła, Kaja
Czeczelewski, Marcin
Flieger, Jolanta
author_sort Baj, Jacek
collection PubMed
description Trace element accumulation varies in different human tissues. Distribution of several elements was found to be disrupted in the case of excessive alcohol consumption, causing negative effects and exacerbation of pathological processes in the liver. In this study, we analyzed the levels and interactions between seven trace elements including calcium (Ca), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), potassium (K), and magnesium (Mg), manganese (Mn), sodium (Na), zinc (Zn), and selenium (Se) in individuals with alcohol-use disorder (AUD) and patients without AUD (control group). The liver samples were collected during autopsy from 39 individuals with AUD and 45 control subjects. Elemental composition inductively coupled plasma optical emission spectrometry (ICP-OES) after wet mineralization by nitric acid was applied for the evaluation of the samples. Positive correlations dominated in the AUD group, mainly in relation to Mg, which strongly positively correlated with Ca, Mn, Fe; K correlated with Mn and Zn, and Cu positively correlated with K and Zn. The strongest positive correlation in the AUD group was observed for the Mg-Mn pair (r = 0.87). Significant statistical differences (p < 0.05) between the groups concerned the average concentration of Co, Cu, Mn, and Mg, which were lower in the AUD group, and Fe, the level of which was significantly higher in the AUD group compared to the control group. Evaluation of the chronic alcohol consumption effect on the accumulation of trace elements in the liver allows a better understanding of the pathological processes taking place in this organ.
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spelling pubmed-88384382022-02-13 Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES Baj, Jacek Teresiński, Grzegorz Forma, Alicja Flieger, Michał Proch, Jędrzej Niedzielski, Przemysław Grochowski, Cezary Blicharska, Eliza Buszewicz, Grzegorz Bogucki, Jacek Majerek, Dariusz Karakuła, Kaja Czeczelewski, Marcin Flieger, Jolanta Nutrients Article Trace element accumulation varies in different human tissues. Distribution of several elements was found to be disrupted in the case of excessive alcohol consumption, causing negative effects and exacerbation of pathological processes in the liver. In this study, we analyzed the levels and interactions between seven trace elements including calcium (Ca), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), potassium (K), and magnesium (Mg), manganese (Mn), sodium (Na), zinc (Zn), and selenium (Se) in individuals with alcohol-use disorder (AUD) and patients without AUD (control group). The liver samples were collected during autopsy from 39 individuals with AUD and 45 control subjects. Elemental composition inductively coupled plasma optical emission spectrometry (ICP-OES) after wet mineralization by nitric acid was applied for the evaluation of the samples. Positive correlations dominated in the AUD group, mainly in relation to Mg, which strongly positively correlated with Ca, Mn, Fe; K correlated with Mn and Zn, and Cu positively correlated with K and Zn. The strongest positive correlation in the AUD group was observed for the Mg-Mn pair (r = 0.87). Significant statistical differences (p < 0.05) between the groups concerned the average concentration of Co, Cu, Mn, and Mg, which were lower in the AUD group, and Fe, the level of which was significantly higher in the AUD group compared to the control group. Evaluation of the chronic alcohol consumption effect on the accumulation of trace elements in the liver allows a better understanding of the pathological processes taking place in this organ. MDPI 2022-01-27 /pmc/articles/PMC8838438/ /pubmed/35276905 http://dx.doi.org/10.3390/nu14030546 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baj, Jacek
Teresiński, Grzegorz
Forma, Alicja
Flieger, Michał
Proch, Jędrzej
Niedzielski, Przemysław
Grochowski, Cezary
Blicharska, Eliza
Buszewicz, Grzegorz
Bogucki, Jacek
Majerek, Dariusz
Karakuła, Kaja
Czeczelewski, Marcin
Flieger, Jolanta
Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES
title Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES
title_full Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES
title_fullStr Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES
title_full_unstemmed Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES
title_short Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES
title_sort chronic alcohol abuse alters hepatic trace element concentrations-metallomic study of hepatic elemental composition by means of icp-oes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838438/
https://www.ncbi.nlm.nih.gov/pubmed/35276905
http://dx.doi.org/10.3390/nu14030546
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