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A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates

Aim: To establish whether the addition of probiotics to a globally accepted Helicobacter pylori (H. pylori)-eradication scheme may reduce the rates of side effects and increase the eradication rates. Methods. Prospective, randomized, placebo-controlled trial of patients receiving eradication therapy...

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Autores principales: Viazis, Nikos, Argyriou, Konstantinos, Kotzampassi, Katerina, Christodoulou, Dimitrios K., Apostolopoulos, Periklis, Georgopoulos, Sotirios D., Liatsos, Christos, Giouleme, Olga, Koustenis, Kanellos, Veretanos, Christos, Stogiannou, Dimitris, Moutzoukis, Miltiadis, Poutakidis, Charalambos, Mylonas, Ioannis Ioardanis, Tseti, Ioulia, Mantzaris, Gerassimos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838490/
https://www.ncbi.nlm.nih.gov/pubmed/35276991
http://dx.doi.org/10.3390/nu14030632
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author Viazis, Nikos
Argyriou, Konstantinos
Kotzampassi, Katerina
Christodoulou, Dimitrios K.
Apostolopoulos, Periklis
Georgopoulos, Sotirios D.
Liatsos, Christos
Giouleme, Olga
Koustenis, Kanellos
Veretanos, Christos
Stogiannou, Dimitris
Moutzoukis, Miltiadis
Poutakidis, Charalambos
Mylonas, Ioannis Ioardanis
Tseti, Ioulia
Mantzaris, Gerassimos J.
author_facet Viazis, Nikos
Argyriou, Konstantinos
Kotzampassi, Katerina
Christodoulou, Dimitrios K.
Apostolopoulos, Periklis
Georgopoulos, Sotirios D.
Liatsos, Christos
Giouleme, Olga
Koustenis, Kanellos
Veretanos, Christos
Stogiannou, Dimitris
Moutzoukis, Miltiadis
Poutakidis, Charalambos
Mylonas, Ioannis Ioardanis
Tseti, Ioulia
Mantzaris, Gerassimos J.
author_sort Viazis, Nikos
collection PubMed
description Aim: To establish whether the addition of probiotics to a globally accepted Helicobacter pylori (H. pylori)-eradication scheme may reduce the rates of side effects and increase the eradication rates. Methods. Prospective, randomized, placebo-controlled trial of patients receiving eradication therapy for H. pylori in the eight participating centers. All patients received a 10-day proton pump inhibitor containing non-bismuth quadruple therapeutic regimen for H. pylori eradication (omeprazole 20 mg, amoxycillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg all twice daily orally) and were randomized to receive either probiotics (group A) or placebo (group B). The probiotic used combined four probiotic strains, i.e., Lactobacillus Acidophilus, Lactiplantibacillus plantarum, Bifidobacterium lactis, and Saccharomyces boulardii. Results. Data were analyzed for 329 patients in group A and 335 patients in group B. Fifty six (17.0%) patients in group A and 170 (50.7%) patients in group B reported the occurrence of an H. pylori treatment-associated new symptom or the aggravation of a pre-existing symptom of any severity (p < 0.00001). H. pylori was successfully eradicated in 303 patients in group A (92.0%) and 291 patients in group B (86.8%), (p = 0.028). Conclusion: Adding probiotics to the 10-day concomitant non-bismuth quadruple H. pylori eradication regimen increases the eradication rate and decreases side effects.
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spelling pubmed-88384902022-02-13 A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates Viazis, Nikos Argyriou, Konstantinos Kotzampassi, Katerina Christodoulou, Dimitrios K. Apostolopoulos, Periklis Georgopoulos, Sotirios D. Liatsos, Christos Giouleme, Olga Koustenis, Kanellos Veretanos, Christos Stogiannou, Dimitris Moutzoukis, Miltiadis Poutakidis, Charalambos Mylonas, Ioannis Ioardanis Tseti, Ioulia Mantzaris, Gerassimos J. Nutrients Article Aim: To establish whether the addition of probiotics to a globally accepted Helicobacter pylori (H. pylori)-eradication scheme may reduce the rates of side effects and increase the eradication rates. Methods. Prospective, randomized, placebo-controlled trial of patients receiving eradication therapy for H. pylori in the eight participating centers. All patients received a 10-day proton pump inhibitor containing non-bismuth quadruple therapeutic regimen for H. pylori eradication (omeprazole 20 mg, amoxycillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg all twice daily orally) and were randomized to receive either probiotics (group A) or placebo (group B). The probiotic used combined four probiotic strains, i.e., Lactobacillus Acidophilus, Lactiplantibacillus plantarum, Bifidobacterium lactis, and Saccharomyces boulardii. Results. Data were analyzed for 329 patients in group A and 335 patients in group B. Fifty six (17.0%) patients in group A and 170 (50.7%) patients in group B reported the occurrence of an H. pylori treatment-associated new symptom or the aggravation of a pre-existing symptom of any severity (p < 0.00001). H. pylori was successfully eradicated in 303 patients in group A (92.0%) and 291 patients in group B (86.8%), (p = 0.028). Conclusion: Adding probiotics to the 10-day concomitant non-bismuth quadruple H. pylori eradication regimen increases the eradication rate and decreases side effects. MDPI 2022-02-01 /pmc/articles/PMC8838490/ /pubmed/35276991 http://dx.doi.org/10.3390/nu14030632 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Viazis, Nikos
Argyriou, Konstantinos
Kotzampassi, Katerina
Christodoulou, Dimitrios K.
Apostolopoulos, Periklis
Georgopoulos, Sotirios D.
Liatsos, Christos
Giouleme, Olga
Koustenis, Kanellos
Veretanos, Christos
Stogiannou, Dimitris
Moutzoukis, Miltiadis
Poutakidis, Charalambos
Mylonas, Ioannis Ioardanis
Tseti, Ioulia
Mantzaris, Gerassimos J.
A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates
title A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates
title_full A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates
title_fullStr A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates
title_full_unstemmed A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates
title_short A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates
title_sort four-probiotics regimen combined with a standard helicobacter pylori-eradication treatment reduces side effects and increases eradication rates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838490/
https://www.ncbi.nlm.nih.gov/pubmed/35276991
http://dx.doi.org/10.3390/nu14030632
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