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Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 ch...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838617/ https://www.ncbi.nlm.nih.gov/pubmed/35276840 http://dx.doi.org/10.3390/nu14030481 |
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author | Long, Julie M. Khandaker, Afsana Mim Sthity, Rahvia Alam Westcott, Jamie E. Matveev, Andrei Black, Robert E. King, Janet C. Islam, Kazi Munisul El Arifeen, Shams Ahmed, Tahmeed Islam, M. Munirul McDonald, Christine M. Krebs, Nancy F. |
author_facet | Long, Julie M. Khandaker, Afsana Mim Sthity, Rahvia Alam Westcott, Jamie E. Matveev, Andrei Black, Robert E. King, Janet C. Islam, Kazi Munisul El Arifeen, Shams Ahmed, Tahmeed Islam, M. Munirul McDonald, Christine M. Krebs, Nancy F. |
author_sort | Long, Julie M. |
collection | PubMed |
description | A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 children who were preventatively supplemented with 10 mg of zinc as part of a multiple micronutrient power (MNP) or as a standalone dispersible tablet for 24 weeks versus a placebo powder. The effects of systemic inflammation on EZP size were also evaluated. Zinc stable isotopes were administered intravenously to children at baseline and endline, and the EZP was measured by the urine extrapolation method. A total of 156 children completed the study with the zinc dispersible tablet group having the greatest increase in EZP (14.1 mg) over 24 weeks when compared with the MNP group (6.8 mg) (p < 0.01) or placebo group (2.0 mg) (p < 0.001). Median EZP size was not different between children with normal or elevated serum inflammatory markers. EZP size was responsive to longitudinal zinc supplementation and reflected the expected difference in bioavailability for two forms of supplementation. The apparent absence of an effect of inflammation on EZP size may offer an advantage for use as a biomarker for group comparisons between different interventions. |
format | Online Article Text |
id | pubmed-8838617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88386172022-02-13 Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation Long, Julie M. Khandaker, Afsana Mim Sthity, Rahvia Alam Westcott, Jamie E. Matveev, Andrei Black, Robert E. King, Janet C. Islam, Kazi Munisul El Arifeen, Shams Ahmed, Tahmeed Islam, M. Munirul McDonald, Christine M. Krebs, Nancy F. Nutrients Article A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 children who were preventatively supplemented with 10 mg of zinc as part of a multiple micronutrient power (MNP) or as a standalone dispersible tablet for 24 weeks versus a placebo powder. The effects of systemic inflammation on EZP size were also evaluated. Zinc stable isotopes were administered intravenously to children at baseline and endline, and the EZP was measured by the urine extrapolation method. A total of 156 children completed the study with the zinc dispersible tablet group having the greatest increase in EZP (14.1 mg) over 24 weeks when compared with the MNP group (6.8 mg) (p < 0.01) or placebo group (2.0 mg) (p < 0.001). Median EZP size was not different between children with normal or elevated serum inflammatory markers. EZP size was responsive to longitudinal zinc supplementation and reflected the expected difference in bioavailability for two forms of supplementation. The apparent absence of an effect of inflammation on EZP size may offer an advantage for use as a biomarker for group comparisons between different interventions. MDPI 2022-01-22 /pmc/articles/PMC8838617/ /pubmed/35276840 http://dx.doi.org/10.3390/nu14030481 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Long, Julie M. Khandaker, Afsana Mim Sthity, Rahvia Alam Westcott, Jamie E. Matveev, Andrei Black, Robert E. King, Janet C. Islam, Kazi Munisul El Arifeen, Shams Ahmed, Tahmeed Islam, M. Munirul McDonald, Christine M. Krebs, Nancy F. Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation |
title | Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation |
title_full | Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation |
title_fullStr | Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation |
title_full_unstemmed | Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation |
title_short | Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation |
title_sort | exchangeable zinc pool size reflects form of zinc supplementation in young children and is not associated with markers of inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838617/ https://www.ncbi.nlm.nih.gov/pubmed/35276840 http://dx.doi.org/10.3390/nu14030481 |
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