Cargando…

Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation

A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Long, Julie M., Khandaker, Afsana Mim, Sthity, Rahvia Alam, Westcott, Jamie E., Matveev, Andrei, Black, Robert E., King, Janet C., Islam, Kazi Munisul, El Arifeen, Shams, Ahmed, Tahmeed, Islam, M. Munirul, McDonald, Christine M., Krebs, Nancy F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838617/
https://www.ncbi.nlm.nih.gov/pubmed/35276840
http://dx.doi.org/10.3390/nu14030481
_version_ 1784650170831470592
author Long, Julie M.
Khandaker, Afsana Mim
Sthity, Rahvia Alam
Westcott, Jamie E.
Matveev, Andrei
Black, Robert E.
King, Janet C.
Islam, Kazi Munisul
El Arifeen, Shams
Ahmed, Tahmeed
Islam, M. Munirul
McDonald, Christine M.
Krebs, Nancy F.
author_facet Long, Julie M.
Khandaker, Afsana Mim
Sthity, Rahvia Alam
Westcott, Jamie E.
Matveev, Andrei
Black, Robert E.
King, Janet C.
Islam, Kazi Munisul
El Arifeen, Shams
Ahmed, Tahmeed
Islam, M. Munirul
McDonald, Christine M.
Krebs, Nancy F.
author_sort Long, Julie M.
collection PubMed
description A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 children who were preventatively supplemented with 10 mg of zinc as part of a multiple micronutrient power (MNP) or as a standalone dispersible tablet for 24 weeks versus a placebo powder. The effects of systemic inflammation on EZP size were also evaluated. Zinc stable isotopes were administered intravenously to children at baseline and endline, and the EZP was measured by the urine extrapolation method. A total of 156 children completed the study with the zinc dispersible tablet group having the greatest increase in EZP (14.1 mg) over 24 weeks when compared with the MNP group (6.8 mg) (p < 0.01) or placebo group (2.0 mg) (p < 0.001). Median EZP size was not different between children with normal or elevated serum inflammatory markers. EZP size was responsive to longitudinal zinc supplementation and reflected the expected difference in bioavailability for two forms of supplementation. The apparent absence of an effect of inflammation on EZP size may offer an advantage for use as a biomarker for group comparisons between different interventions.
format Online
Article
Text
id pubmed-8838617
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88386172022-02-13 Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation Long, Julie M. Khandaker, Afsana Mim Sthity, Rahvia Alam Westcott, Jamie E. Matveev, Andrei Black, Robert E. King, Janet C. Islam, Kazi Munisul El Arifeen, Shams Ahmed, Tahmeed Islam, M. Munirul McDonald, Christine M. Krebs, Nancy F. Nutrients Article A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 children who were preventatively supplemented with 10 mg of zinc as part of a multiple micronutrient power (MNP) or as a standalone dispersible tablet for 24 weeks versus a placebo powder. The effects of systemic inflammation on EZP size were also evaluated. Zinc stable isotopes were administered intravenously to children at baseline and endline, and the EZP was measured by the urine extrapolation method. A total of 156 children completed the study with the zinc dispersible tablet group having the greatest increase in EZP (14.1 mg) over 24 weeks when compared with the MNP group (6.8 mg) (p < 0.01) or placebo group (2.0 mg) (p < 0.001). Median EZP size was not different between children with normal or elevated serum inflammatory markers. EZP size was responsive to longitudinal zinc supplementation and reflected the expected difference in bioavailability for two forms of supplementation. The apparent absence of an effect of inflammation on EZP size may offer an advantage for use as a biomarker for group comparisons between different interventions. MDPI 2022-01-22 /pmc/articles/PMC8838617/ /pubmed/35276840 http://dx.doi.org/10.3390/nu14030481 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Long, Julie M.
Khandaker, Afsana Mim
Sthity, Rahvia Alam
Westcott, Jamie E.
Matveev, Andrei
Black, Robert E.
King, Janet C.
Islam, Kazi Munisul
El Arifeen, Shams
Ahmed, Tahmeed
Islam, M. Munirul
McDonald, Christine M.
Krebs, Nancy F.
Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
title Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
title_full Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
title_fullStr Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
title_full_unstemmed Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
title_short Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
title_sort exchangeable zinc pool size reflects form of zinc supplementation in young children and is not associated with markers of inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838617/
https://www.ncbi.nlm.nih.gov/pubmed/35276840
http://dx.doi.org/10.3390/nu14030481
work_keys_str_mv AT longjuliem exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT khandakerafsanamim exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT sthityrahviaalam exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT westcottjamiee exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT matveevandrei exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT blackroberte exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT kingjanetc exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT islamkazimunisul exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT elarifeenshams exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT ahmedtahmeed exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT islammmunirul exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT mcdonaldchristinem exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation
AT krebsnancyf exchangeablezincpoolsizereflectsformofzincsupplementationinyoungchildrenandisnotassociatedwithmarkersofinflammation