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Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain

Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA in...

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Autores principales: Tahaei, Hana, Gignac, Florence, Pinar, Ariadna, Fernandez-Barrés, Silvia, Romaguera, Dora, Vioque, Jesus, Santa-Marina, Loreto, Subiza-Pérez, Mikel, Llop, Sabrina, Soler-Blasco, Raquel, Arija, Victoria, Salas-Salvadó, Jordi, Tardón, Adonina, Riaño-Galán, Isolina, Sunyer, Jordi, Guxens, Monica, Julvez, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838693/
https://www.ncbi.nlm.nih.gov/pubmed/35276877
http://dx.doi.org/10.3390/nu14030518
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author Tahaei, Hana
Gignac, Florence
Pinar, Ariadna
Fernandez-Barrés, Silvia
Romaguera, Dora
Vioque, Jesus
Santa-Marina, Loreto
Subiza-Pérez, Mikel
Llop, Sabrina
Soler-Blasco, Raquel
Arija, Victoria
Salas-Salvadó, Jordi
Tardón, Adonina
Riaño-Galán, Isolina
Sunyer, Jordi
Guxens, Monica
Julvez, Jordi
author_facet Tahaei, Hana
Gignac, Florence
Pinar, Ariadna
Fernandez-Barrés, Silvia
Romaguera, Dora
Vioque, Jesus
Santa-Marina, Loreto
Subiza-Pérez, Mikel
Llop, Sabrina
Soler-Blasco, Raquel
Arija, Victoria
Salas-Salvadó, Jordi
Tardón, Adonina
Riaño-Galán, Isolina
Sunyer, Jordi
Guxens, Monica
Julvez, Jordi
author_sort Tahaei, Hana
collection PubMed
description Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child’s neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children’s Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: −22.95, −0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.
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spelling pubmed-88386932022-02-13 Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain Tahaei, Hana Gignac, Florence Pinar, Ariadna Fernandez-Barrés, Silvia Romaguera, Dora Vioque, Jesus Santa-Marina, Loreto Subiza-Pérez, Mikel Llop, Sabrina Soler-Blasco, Raquel Arija, Victoria Salas-Salvadó, Jordi Tardón, Adonina Riaño-Galán, Isolina Sunyer, Jordi Guxens, Monica Julvez, Jordi Nutrients Article Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child’s neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children’s Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: −22.95, −0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings. MDPI 2022-01-25 /pmc/articles/PMC8838693/ /pubmed/35276877 http://dx.doi.org/10.3390/nu14030518 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tahaei, Hana
Gignac, Florence
Pinar, Ariadna
Fernandez-Barrés, Silvia
Romaguera, Dora
Vioque, Jesus
Santa-Marina, Loreto
Subiza-Pérez, Mikel
Llop, Sabrina
Soler-Blasco, Raquel
Arija, Victoria
Salas-Salvadó, Jordi
Tardón, Adonina
Riaño-Galán, Isolina
Sunyer, Jordi
Guxens, Monica
Julvez, Jordi
Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_full Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_fullStr Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_full_unstemmed Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_short Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain
title_sort omega-3 fatty acid intake during pregnancy and child neuropsychological development: a multi-centre population-based birth cohort study in spain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838693/
https://www.ncbi.nlm.nih.gov/pubmed/35276877
http://dx.doi.org/10.3390/nu14030518
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