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The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders

The gut microbiota is a complex community of microorganisms that has become a new focus of attention due to its association with numerous human diseases. Research over the last few decades has shown that the gut microbiota plays a considerable role in regulating intestinal homeostasis, and disruptio...

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Autores principales: Islam, Maafi R., Arthur, Subha, Haynes, Jennifer, Butts, Molly R., Nepal, Niraj, Sundaram, Uma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838694/
https://www.ncbi.nlm.nih.gov/pubmed/35276983
http://dx.doi.org/10.3390/nu14030624
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author Islam, Maafi R.
Arthur, Subha
Haynes, Jennifer
Butts, Molly R.
Nepal, Niraj
Sundaram, Uma
author_facet Islam, Maafi R.
Arthur, Subha
Haynes, Jennifer
Butts, Molly R.
Nepal, Niraj
Sundaram, Uma
author_sort Islam, Maafi R.
collection PubMed
description The gut microbiota is a complex community of microorganisms that has become a new focus of attention due to its association with numerous human diseases. Research over the last few decades has shown that the gut microbiota plays a considerable role in regulating intestinal homeostasis, and disruption to the microbial community has been linked to chronic disease conditions such as inflammatory bowel disease (IBD), colorectal cancer (CRC), and obesity. Obesity has become a global pandemic, and its prevalence is increasing worldwide mostly in Western countries due to a sedentary lifestyle and consumption of high-fat/high-sugar diets. Obesity-mediated gut microbiota alterations have been associated with the development of IBD and IBD-induced CRC. This review highlights how obesity-associated dysbiosis can lead to the pathogenesis of IBD and CRC with a special focus on mechanisms of altered absorption of short-chain fatty acids (SCFAs).
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spelling pubmed-88386942022-02-13 The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders Islam, Maafi R. Arthur, Subha Haynes, Jennifer Butts, Molly R. Nepal, Niraj Sundaram, Uma Nutrients Review The gut microbiota is a complex community of microorganisms that has become a new focus of attention due to its association with numerous human diseases. Research over the last few decades has shown that the gut microbiota plays a considerable role in regulating intestinal homeostasis, and disruption to the microbial community has been linked to chronic disease conditions such as inflammatory bowel disease (IBD), colorectal cancer (CRC), and obesity. Obesity has become a global pandemic, and its prevalence is increasing worldwide mostly in Western countries due to a sedentary lifestyle and consumption of high-fat/high-sugar diets. Obesity-mediated gut microbiota alterations have been associated with the development of IBD and IBD-induced CRC. This review highlights how obesity-associated dysbiosis can lead to the pathogenesis of IBD and CRC with a special focus on mechanisms of altered absorption of short-chain fatty acids (SCFAs). MDPI 2022-01-31 /pmc/articles/PMC8838694/ /pubmed/35276983 http://dx.doi.org/10.3390/nu14030624 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Islam, Maafi R.
Arthur, Subha
Haynes, Jennifer
Butts, Molly R.
Nepal, Niraj
Sundaram, Uma
The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders
title The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders
title_full The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders
title_fullStr The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders
title_full_unstemmed The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders
title_short The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders
title_sort role of gut microbiota and metabolites in obesity-associated chronic gastrointestinal disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838694/
https://www.ncbi.nlm.nih.gov/pubmed/35276983
http://dx.doi.org/10.3390/nu14030624
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