Comparison of Proton Acceptor and Proton Donor Properties of H(2)O and H(2)O(2) in Organic Crystals of Drug-like Compounds: Peroxosolvates vs. Crystallohydrates

Two new peroxosolvates of drug-like compounds were synthesized and studied by a combination of X-ray crystallographic, Raman spectroscopic methods, and periodic DFT computations. The enthalpies of H-bonds formed by hydrogen peroxide (H(2)O(2)) as a donor and an acceptor of protons were compared with the enthalpies of analogous H-bonds formed by water (H(2)O) in isomorphic (isostructural) hydrates. The enthalpies of H-bonds formed by H(2)O(2) as a proton donor turned out to be higher than the values of the corresponding H-bonds formed by H(2)O. In the case of H(2)O(2) as a proton acceptor in H-bonds, the ratio appeared reversed. The neutral O∙∙∙H-O/O∙∙∙H-N bonds formed by the lone electron pair of the oxygen atom of water were the strongest H-bonds in the considered crystals. In the paper, it was found out that the low-frequency Raman spectra of isomorphous crystalline hydrate and peroxosolvate of N-(5-Nitro-2-furfurylidene)-1-aminohydantoin are similar. As for the isostructural hydrate and peroxosolvate of the salt of protonated 2-amino-nicotinic acid and maleic acid monoanion, the Raman spectra are different.