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Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides
Highly efficient stereoselective syntheses of novel bis(E-2-chlorovinyl) selenides and bis(E-2-bromovinyl) selenides in quantitative yields by reactions of selenium dichloride and dibromide with alkynes were developed. The reactions proceeded at room temperature as anti-addition giving products excl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838769/ https://www.ncbi.nlm.nih.gov/pubmed/35164315 http://dx.doi.org/10.3390/molecules27031050 |
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author | Musalov, Maxim V. Potapov, Vladimir A. Maylyan, Arkady A. Khabibulina, Alfiya G. Zinchenko, Sergey V. Amosova, Svetlana V. |
author_facet | Musalov, Maxim V. Potapov, Vladimir A. Maylyan, Arkady A. Khabibulina, Alfiya G. Zinchenko, Sergey V. Amosova, Svetlana V. |
author_sort | Musalov, Maxim V. |
collection | PubMed |
description | Highly efficient stereoselective syntheses of novel bis(E-2-chlorovinyl) selenides and bis(E-2-bromovinyl) selenides in quantitative yields by reactions of selenium dichloride and dibromide with alkynes were developed. The reactions proceeded at room temperature as anti-addition giving products exclusively with (E)-stereochemistry. The glutathione peroxidase-like activity of the obtained products was estimated and compounds with high activity were found. The influence of substituents in the products on their glutathione peroxidase-like activity was discussed. |
format | Online Article Text |
id | pubmed-8838769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88387692022-02-13 Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides Musalov, Maxim V. Potapov, Vladimir A. Maylyan, Arkady A. Khabibulina, Alfiya G. Zinchenko, Sergey V. Amosova, Svetlana V. Molecules Article Highly efficient stereoselective syntheses of novel bis(E-2-chlorovinyl) selenides and bis(E-2-bromovinyl) selenides in quantitative yields by reactions of selenium dichloride and dibromide with alkynes were developed. The reactions proceeded at room temperature as anti-addition giving products exclusively with (E)-stereochemistry. The glutathione peroxidase-like activity of the obtained products was estimated and compounds with high activity were found. The influence of substituents in the products on their glutathione peroxidase-like activity was discussed. MDPI 2022-02-03 /pmc/articles/PMC8838769/ /pubmed/35164315 http://dx.doi.org/10.3390/molecules27031050 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Musalov, Maxim V. Potapov, Vladimir A. Maylyan, Arkady A. Khabibulina, Alfiya G. Zinchenko, Sergey V. Amosova, Svetlana V. Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides |
title | Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides |
title_full | Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides |
title_fullStr | Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides |
title_full_unstemmed | Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides |
title_short | Selenium Dihalides Click Chemistry: Highly Efficient Stereoselective Addition to Alkynes and Evaluation of Glutathione Peroxidase-Like Activity of Bis(E-2-halovinyl) Selenides |
title_sort | selenium dihalides click chemistry: highly efficient stereoselective addition to alkynes and evaluation of glutathione peroxidase-like activity of bis(e-2-halovinyl) selenides |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838769/ https://www.ncbi.nlm.nih.gov/pubmed/35164315 http://dx.doi.org/10.3390/molecules27031050 |
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