Cargando…

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

As cannabinoid CB2 receptors (CB2R) possess various pharmacological effects—including anti-epilepsy, analgesia, anti-inflammation, anti-fibrosis, and regulation of bone metabolism—without the psychoactive side effects induced by cannabinoid CB1R activation, they have become the focus of research and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Si-Jing, Cheng, Gang, Zhou, Hao, Zhang, Qi, Zhang, Quan-Long, Wang, Yang, Shen, Yi, Lian, Chen-Xia, Ma, Xue-Qin, Zhang, Qiao-Yan, Qin, Lu-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838898/ https://www.ncbi.nlm.nih.gov/pubmed/35163968 http://dx.doi.org/10.3390/molecules27030702

Ejemplares similares

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018
por: Finlay, David B., et al.
Publicado: (2022)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity
por: Franks, Lirit N., et al.
Publicado: (2016)

Evaluation of carboxamide-type synthetic cannabinoids as CB(1)/CB(2) receptor agonists: difference between the enantiomers
por: Doi, Takahiro, et al.
Publicado: (2017)

Anti-inflammatory and antinociceptive effects of the selective cannabinoid CB(2) receptor agonist ABK5
por: Tang, Yaliang, et al.
Publicado: (2020)

Characterization of Subtype Selective Cannabinoid CB(2) Receptor Agonists as Potential Anti-Inflammatory Agents
por: Tang, Yaliang, et al.
Publicado: (2021)

Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway
por: Yang, Shuai, et al.
Publicado: (2020)

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB(1)/CB(2) Receptor Interaction
por: Asproni, Battistina, et al.
Publicado: (2021)

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
por: Polini, Beatrice, et al.
Publicado: (2020)

Vascular Dysfunction in a Transgenic Model of Alzheimer's Disease: Effects of CB1R and CB2R Cannabinoid Agonists
por: Navarro-Dorado, Jorge, et al.
Publicado: (2016)

Cannabinoid CB(1) and CB(2) Receptor Signaling and Bias
por: Ibsen, Mikkel Søes, et al.
Publicado: (2017)

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties
por: de Oliveira, Daniela R., et al.
Publicado: (2022)

Effects of the cannabinoid CB(1) agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs
por: Berger, Joel I., et al.
Publicado: (2017)

Cannabigerol Action at Cannabinoid CB(1) and CB(2) Receptors and at CB(1)–CB(2) Heteroreceptor Complexes
por: Navarro, Gemma, et al.
Publicado: (2018)

Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells
por: Capozzi, Antonella, et al.
Publicado: (2018)

Cannabinoid receptor subtype 2 (CB(2)R) agonist, GW405833 reduces agonist-induced Ca(2+) oscillations in mouse pancreatic acinar cells
por: Huang, Zebing, et al.
Publicado: (2016)

Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB(2) Receptor
por: Taylor, Lewis, et al.
Publicado: (2015)

Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
por: Jiang, Shuxian, et al.
Publicado: (2007)

The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation
por: Bow, Eric W., et al.
Publicado: (2016)

Cannabinoid CB1 receptors regulate salivation
por: Andreis, Kelsey, et al.
Publicado: (2022)

Voltage dependence of the cannabinoid CB1 receptor
por: Goldberger, Esty, et al.
Publicado: (2022)

Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
por: Capozzi, Antonella, et al.
Publicado: (2021)

Brain Cannabinoid CB(2) Receptors Modulate Cocaine’s Actions in Mice
por: Xi, Zheng-Xiong, et al.
Publicado: (2011)

Cannabinoid CB(1) Receptor Agonists Do Not Decrease, but may Increase Acoustic Trauma-Induced Tinnitus in Rats
por: Zheng, Yiwen, et al.
Publicado: (2015)

Antiallodynic Effects of Cannabinoid Receptor 2 (CB(2)R) Agonists on Retrovirus Infection-Induced Neuropathic Pain
por: Sheng, Wen S., et al.
Publicado: (2019)

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys
por: Bouskila, Joseph, et al.
Publicado: (2016)

The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone‐Induced Central Nervous System Demyelination
por: Tomas‐Roig, Jordi, et al.
Publicado: (2016)

Cannabinoid Receptor CB(2) Modulates Axon Guidance
por: Duff, Gabriel, et al.
Publicado: (2013)

CB1 Cannabinoid Receptor Signaling and Biased Signaling
por: Leo, Luciana M., et al.
Publicado: (2021)

Editorial: Therapeutic potential of the cannabinoid CB2 receptor
por: Smoum, Reem, et al.
Publicado: (2022)

Microglial Cannabinoid CB(2) Receptors in Pain Modulation
por: Xu, Kangtai, et al.
Publicado: (2023)

Effects of a Selective Cannabinoid CB2 Agonist and Antagonist on Intravenous Nicotine Self Administration and Reinstatement of Nicotine Seeking
por: Gamaleddin, Islam, et al.
Publicado: (2012)

Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells
por: Gado, Francesca, et al.
Publicado: (2022)

Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor
por: Yano, Hideaki, et al.
Publicado: (2023)

Effects of pro‐inflammatory cytokines on cannabinoid CB (1) and CB (2) receptors in immune cells
por: Jean‐Gilles, L., et al.
Publicado: (2015)

Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms
por: Soderstrom, Ken, et al.
Publicado: (2017)

Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction
por: Fish, Eric W., et al.
Publicado: (2019)

An Update on Non-CB(1), Non-CB(2) Cannabinoid Related G-Protein-Coupled Receptors
por: Morales, Paula, et al.
Publicado: (2017)

Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
por: Manzanedo, Carmen, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_kqe7d3p4rl4khivikqgj4ecb29