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Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders
Cardiovascular disorders (CVDs) are the leading risk factor for death worldwide, and research into the processes and treatment regimens has received a lot of attention. Tilianin is a flavonoid glycoside that can be found in a wide range of medicinal plants and is most commonly obtained from Dracocep...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838974/ https://www.ncbi.nlm.nih.gov/pubmed/35163934 http://dx.doi.org/10.3390/molecules27030673 |
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author | Khattulanuar, Farrah Syazana Sekar, Mahendran Fuloria, Shivkanya Gan, Siew Hua Rani, Nur Najihah Izzati Mat Ravi, Subban Chidambaram, Kumarappan Begum, M. Yasmin Azad, Abul Kalam Jeyabalan, Srikanth Dhiravidamani, Arulmozhi Thangavelu, Lakshmi Lum, Pei Teng Subramaniyan, Vetriselvan Wu, Yuan Seng Sathasivam, Kathiresan V. Fuloria, Neeraj Kumar |
author_facet | Khattulanuar, Farrah Syazana Sekar, Mahendran Fuloria, Shivkanya Gan, Siew Hua Rani, Nur Najihah Izzati Mat Ravi, Subban Chidambaram, Kumarappan Begum, M. Yasmin Azad, Abul Kalam Jeyabalan, Srikanth Dhiravidamani, Arulmozhi Thangavelu, Lakshmi Lum, Pei Teng Subramaniyan, Vetriselvan Wu, Yuan Seng Sathasivam, Kathiresan V. Fuloria, Neeraj Kumar |
author_sort | Khattulanuar, Farrah Syazana |
collection | PubMed |
description | Cardiovascular disorders (CVDs) are the leading risk factor for death worldwide, and research into the processes and treatment regimens has received a lot of attention. Tilianin is a flavonoid glycoside that can be found in a wide range of medicinal plants and is most commonly obtained from Dracocephalum moldavica. Due to its extensive range of biological actions, it has become a well-known molecule in recent years. In particular, numerous studies have shown that tilianin has cardioprotective properties against CVDs. Hence, this review summarises tilianin’s preclinical research in CVDs, as well as its mechanism of action and opportunities in future drug development. The physicochemical and drug-likeness properties, as well as the toxicity profile, were also highlighted. Tilianin can be a natural lead molecule in the therapy of CVDs such as coronary heart disease, angina pectoris, hypertension, and myocardial ischemia, according to scientific evidence. Free radical scavenging, inflammation control, mitochondrial function regulation, and related signalling pathways are all thought to play a role in tilianin’s cardioprotective actions. Finally, we discuss tilianin-derived compounds, as well as the limitations and opportunities of using tilianin as a lead molecule in drug development for CVDs. Overall, the scientific evidence presented in this review supports that tilianin and its derivatives could be used as a lead molecule in CVD drug development initiatives. |
format | Online Article Text |
id | pubmed-8838974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88389742022-02-13 Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders Khattulanuar, Farrah Syazana Sekar, Mahendran Fuloria, Shivkanya Gan, Siew Hua Rani, Nur Najihah Izzati Mat Ravi, Subban Chidambaram, Kumarappan Begum, M. Yasmin Azad, Abul Kalam Jeyabalan, Srikanth Dhiravidamani, Arulmozhi Thangavelu, Lakshmi Lum, Pei Teng Subramaniyan, Vetriselvan Wu, Yuan Seng Sathasivam, Kathiresan V. Fuloria, Neeraj Kumar Molecules Review Cardiovascular disorders (CVDs) are the leading risk factor for death worldwide, and research into the processes and treatment regimens has received a lot of attention. Tilianin is a flavonoid glycoside that can be found in a wide range of medicinal plants and is most commonly obtained from Dracocephalum moldavica. Due to its extensive range of biological actions, it has become a well-known molecule in recent years. In particular, numerous studies have shown that tilianin has cardioprotective properties against CVDs. Hence, this review summarises tilianin’s preclinical research in CVDs, as well as its mechanism of action and opportunities in future drug development. The physicochemical and drug-likeness properties, as well as the toxicity profile, were also highlighted. Tilianin can be a natural lead molecule in the therapy of CVDs such as coronary heart disease, angina pectoris, hypertension, and myocardial ischemia, according to scientific evidence. Free radical scavenging, inflammation control, mitochondrial function regulation, and related signalling pathways are all thought to play a role in tilianin’s cardioprotective actions. Finally, we discuss tilianin-derived compounds, as well as the limitations and opportunities of using tilianin as a lead molecule in drug development for CVDs. Overall, the scientific evidence presented in this review supports that tilianin and its derivatives could be used as a lead molecule in CVD drug development initiatives. MDPI 2022-01-20 /pmc/articles/PMC8838974/ /pubmed/35163934 http://dx.doi.org/10.3390/molecules27030673 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khattulanuar, Farrah Syazana Sekar, Mahendran Fuloria, Shivkanya Gan, Siew Hua Rani, Nur Najihah Izzati Mat Ravi, Subban Chidambaram, Kumarappan Begum, M. Yasmin Azad, Abul Kalam Jeyabalan, Srikanth Dhiravidamani, Arulmozhi Thangavelu, Lakshmi Lum, Pei Teng Subramaniyan, Vetriselvan Wu, Yuan Seng Sathasivam, Kathiresan V. Fuloria, Neeraj Kumar Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders |
title | Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders |
title_full | Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders |
title_fullStr | Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders |
title_full_unstemmed | Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders |
title_short | Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders |
title_sort | tilianin: a potential natural lead molecule for new drug design and development for the treatment of cardiovascular disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838974/ https://www.ncbi.nlm.nih.gov/pubmed/35163934 http://dx.doi.org/10.3390/molecules27030673 |
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