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Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy

Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact betw...

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Detalles Bibliográficos
Autores principales: Torres-Pastor, Miguel Ángel, Espro, Claudia, Selva, Maurizio, Perosa, Alvise, Romero Reyes, Antonio A., Osman, Sameh M., Luque, Rafael, Rodríguez-Padrón, Daily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838984/
https://www.ncbi.nlm.nih.gov/pubmed/35163895
http://dx.doi.org/10.3390/molecules27030632
Descripción
Sumario:Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact between the reagents, and greatly favors the higher conversion of aminophenol. At the same time, following a mechanochemical–microwave sequential approach could tune the selectivity towards the formation of a benzoxazine derivative, which could find application in a wide range of biomedical areas.