Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy

Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact betw...

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Autores principales: Torres-Pastor, Miguel Ángel, Espro, Claudia, Selva, Maurizio, Perosa, Alvise, Romero Reyes, Antonio A., Osman, Sameh M., Luque, Rafael, Rodríguez-Padrón, Daily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838984/
https://www.ncbi.nlm.nih.gov/pubmed/35163895
http://dx.doi.org/10.3390/molecules27030632
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author Torres-Pastor, Miguel Ángel
Espro, Claudia
Selva, Maurizio
Perosa, Alvise
Romero Reyes, Antonio A.
Osman, Sameh M.
Luque, Rafael
Rodríguez-Padrón, Daily
author_facet Torres-Pastor, Miguel Ángel
Espro, Claudia
Selva, Maurizio
Perosa, Alvise
Romero Reyes, Antonio A.
Osman, Sameh M.
Luque, Rafael
Rodríguez-Padrón, Daily
author_sort Torres-Pastor, Miguel Ángel
collection PubMed
description Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact between the reagents, and greatly favors the higher conversion of aminophenol. At the same time, following a mechanochemical–microwave sequential approach could tune the selectivity towards the formation of a benzoxazine derivative, which could find application in a wide range of biomedical areas.
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spelling pubmed-88389842022-02-13 Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy Torres-Pastor, Miguel Ángel Espro, Claudia Selva, Maurizio Perosa, Alvise Romero Reyes, Antonio A. Osman, Sameh M. Luque, Rafael Rodríguez-Padrón, Daily Molecules Article Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact between the reagents, and greatly favors the higher conversion of aminophenol. At the same time, following a mechanochemical–microwave sequential approach could tune the selectivity towards the formation of a benzoxazine derivative, which could find application in a wide range of biomedical areas. MDPI 2022-01-19 /pmc/articles/PMC8838984/ /pubmed/35163895 http://dx.doi.org/10.3390/molecules27030632 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torres-Pastor, Miguel Ángel
Espro, Claudia
Selva, Maurizio
Perosa, Alvise
Romero Reyes, Antonio A.
Osman, Sameh M.
Luque, Rafael
Rodríguez-Padrón, Daily
Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy
title Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy
title_full Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy
title_fullStr Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy
title_full_unstemmed Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy
title_short Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy
title_sort glycerol valorization towards a benzoxazine derivative through a milling and microwave sequential strategy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838984/
https://www.ncbi.nlm.nih.gov/pubmed/35163895
http://dx.doi.org/10.3390/molecules27030632
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