An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology

The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system is best known for its role in genomic editing. It has also demonstrated great potential in nucleic acid biosensing. However, the specificity limitation in CRISPR/Cas has created a hurdle for its advancement. More recent...

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Detalles Bibliográficos
Autores principales: Roueinfar, Mina, Templeton, Hayley N., Sheng, Julietta A., Hong, Ka Lok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839139/
https://www.ncbi.nlm.nih.gov/pubmed/35164379
http://dx.doi.org/10.3390/molecules27031114
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author Roueinfar, Mina
Templeton, Hayley N.
Sheng, Julietta A.
Hong, Ka Lok
author_facet Roueinfar, Mina
Templeton, Hayley N.
Sheng, Julietta A.
Hong, Ka Lok
author_sort Roueinfar, Mina
collection PubMed
description The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system is best known for its role in genomic editing. It has also demonstrated great potential in nucleic acid biosensing. However, the specificity limitation in CRISPR/Cas has created a hurdle for its advancement. More recently, nucleic acid aptamers known for their high affinity and specificity properties for their targets have been integrated into CRISPR/Cas systems. This review article gives a brief overview of the aptamer and CRISPR/Cas technology and provides an updated summary and discussion on how the two distinctive nucleic acid technologies are being integrated into modern diagnostic and therapeutic applications
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spelling pubmed-88391392022-02-13 An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology Roueinfar, Mina Templeton, Hayley N. Sheng, Julietta A. Hong, Ka Lok Molecules Review The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system is best known for its role in genomic editing. It has also demonstrated great potential in nucleic acid biosensing. However, the specificity limitation in CRISPR/Cas has created a hurdle for its advancement. More recently, nucleic acid aptamers known for their high affinity and specificity properties for their targets have been integrated into CRISPR/Cas systems. This review article gives a brief overview of the aptamer and CRISPR/Cas technology and provides an updated summary and discussion on how the two distinctive nucleic acid technologies are being integrated into modern diagnostic and therapeutic applications MDPI 2022-02-07 /pmc/articles/PMC8839139/ /pubmed/35164379 http://dx.doi.org/10.3390/molecules27031114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roueinfar, Mina
Templeton, Hayley N.
Sheng, Julietta A.
Hong, Ka Lok
An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology
title An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology
title_full An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology
title_fullStr An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology
title_full_unstemmed An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology
title_short An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology
title_sort update of nucleic acids aptamers theranostic integration with crispr/cas technology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839139/
https://www.ncbi.nlm.nih.gov/pubmed/35164379
http://dx.doi.org/10.3390/molecules27031114
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