Cargando…
Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release
Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active c...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839200/ https://www.ncbi.nlm.nih.gov/pubmed/35160362 http://dx.doi.org/10.3390/polym14030373 |
_version_ | 1784650312059977728 |
---|---|
author | Volokhova, Apollinariya A. Fedorishin, Dmitry A. Khvastunova, Arina O. Spiridonova, Tatiana I. Kozelskaya, Anna I. Kzhyshkowska, Julia Tverdokhlebov, Sergei I. Kurzina, Irina |
author_facet | Volokhova, Apollinariya A. Fedorishin, Dmitry A. Khvastunova, Arina O. Spiridonova, Tatiana I. Kozelskaya, Anna I. Kzhyshkowska, Julia Tverdokhlebov, Sergei I. Kurzina, Irina |
author_sort | Volokhova, Apollinariya A. |
collection | PubMed |
description | Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active chemical bonds in the near-surface layers, are the main reasons for the described effect. These surface effects are also known to increase the release rate of drugs incorporated in fibers. Herein, we investigated the effect of plasma modification on the chloramphenicol release from electrospun poly (lactic acid) fibrous scaffolds. Scaffolds with high—50 wt./wt.%—drug content were obtained. It was shown that plasma modification leads to an increase in the drug release rate and drug diffusion coefficient, while not deteriorating surface morphology and mechanical properties of scaffolds. The materials’ antibacterial activity was observed to increase in the first day of the experiment, while remaining on the same level as the unmodified group during the next six days. The proposed technique for modifying the surface of scaffolds will be useful for obtaining drug delivery systems with controlled accelerated release, which can expand the possibilities of local applications of antibiotics and other drugs. |
format | Online Article Text |
id | pubmed-8839200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88392002022-02-13 Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release Volokhova, Apollinariya A. Fedorishin, Dmitry A. Khvastunova, Arina O. Spiridonova, Tatiana I. Kozelskaya, Anna I. Kzhyshkowska, Julia Tverdokhlebov, Sergei I. Kurzina, Irina Polymers (Basel) Article Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active chemical bonds in the near-surface layers, are the main reasons for the described effect. These surface effects are also known to increase the release rate of drugs incorporated in fibers. Herein, we investigated the effect of plasma modification on the chloramphenicol release from electrospun poly (lactic acid) fibrous scaffolds. Scaffolds with high—50 wt./wt.%—drug content were obtained. It was shown that plasma modification leads to an increase in the drug release rate and drug diffusion coefficient, while not deteriorating surface morphology and mechanical properties of scaffolds. The materials’ antibacterial activity was observed to increase in the first day of the experiment, while remaining on the same level as the unmodified group during the next six days. The proposed technique for modifying the surface of scaffolds will be useful for obtaining drug delivery systems with controlled accelerated release, which can expand the possibilities of local applications of antibiotics and other drugs. MDPI 2022-01-18 /pmc/articles/PMC8839200/ /pubmed/35160362 http://dx.doi.org/10.3390/polym14030373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Volokhova, Apollinariya A. Fedorishin, Dmitry A. Khvastunova, Arina O. Spiridonova, Tatiana I. Kozelskaya, Anna I. Kzhyshkowska, Julia Tverdokhlebov, Sergei I. Kurzina, Irina Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release |
title | Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release |
title_full | Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release |
title_fullStr | Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release |
title_full_unstemmed | Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release |
title_short | Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release |
title_sort | reactive magnetron plasma modification of electrospun plla scaffolds with incorporated chloramphenicol for controlled drug release |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839200/ https://www.ncbi.nlm.nih.gov/pubmed/35160362 http://dx.doi.org/10.3390/polym14030373 |
work_keys_str_mv | AT volokhovaapollinariyaa reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease AT fedorishindmitrya reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease AT khvastunovaarinao reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease AT spiridonovatatianai reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease AT kozelskayaannai reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease AT kzhyshkowskajulia reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease AT tverdokhlebovsergeii reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease AT kurzinairina reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease |