Cargando…

Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release

Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active c...

Descripción completa

Detalles Bibliográficos
Autores principales: Volokhova, Apollinariya A., Fedorishin, Dmitry A., Khvastunova, Arina O., Spiridonova, Tatiana I., Kozelskaya, Anna I., Kzhyshkowska, Julia, Tverdokhlebov, Sergei I., Kurzina, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839200/
https://www.ncbi.nlm.nih.gov/pubmed/35160362
http://dx.doi.org/10.3390/polym14030373
_version_ 1784650312059977728
author Volokhova, Apollinariya A.
Fedorishin, Dmitry A.
Khvastunova, Arina O.
Spiridonova, Tatiana I.
Kozelskaya, Anna I.
Kzhyshkowska, Julia
Tverdokhlebov, Sergei I.
Kurzina, Irina
author_facet Volokhova, Apollinariya A.
Fedorishin, Dmitry A.
Khvastunova, Arina O.
Spiridonova, Tatiana I.
Kozelskaya, Anna I.
Kzhyshkowska, Julia
Tverdokhlebov, Sergei I.
Kurzina, Irina
author_sort Volokhova, Apollinariya A.
collection PubMed
description Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active chemical bonds in the near-surface layers, are the main reasons for the described effect. These surface effects are also known to increase the release rate of drugs incorporated in fibers. Herein, we investigated the effect of plasma modification on the chloramphenicol release from electrospun poly (lactic acid) fibrous scaffolds. Scaffolds with high—50 wt./wt.%—drug content were obtained. It was shown that plasma modification leads to an increase in the drug release rate and drug diffusion coefficient, while not deteriorating surface morphology and mechanical properties of scaffolds. The materials’ antibacterial activity was observed to increase in the first day of the experiment, while remaining on the same level as the unmodified group during the next six days. The proposed technique for modifying the surface of scaffolds will be useful for obtaining drug delivery systems with controlled accelerated release, which can expand the possibilities of local applications of antibiotics and other drugs.
format Online
Article
Text
id pubmed-8839200
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88392002022-02-13 Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release Volokhova, Apollinariya A. Fedorishin, Dmitry A. Khvastunova, Arina O. Spiridonova, Tatiana I. Kozelskaya, Anna I. Kzhyshkowska, Julia Tverdokhlebov, Sergei I. Kurzina, Irina Polymers (Basel) Article Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active chemical bonds in the near-surface layers, are the main reasons for the described effect. These surface effects are also known to increase the release rate of drugs incorporated in fibers. Herein, we investigated the effect of plasma modification on the chloramphenicol release from electrospun poly (lactic acid) fibrous scaffolds. Scaffolds with high—50 wt./wt.%—drug content were obtained. It was shown that plasma modification leads to an increase in the drug release rate and drug diffusion coefficient, while not deteriorating surface morphology and mechanical properties of scaffolds. The materials’ antibacterial activity was observed to increase in the first day of the experiment, while remaining on the same level as the unmodified group during the next six days. The proposed technique for modifying the surface of scaffolds will be useful for obtaining drug delivery systems with controlled accelerated release, which can expand the possibilities of local applications of antibiotics and other drugs. MDPI 2022-01-18 /pmc/articles/PMC8839200/ /pubmed/35160362 http://dx.doi.org/10.3390/polym14030373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Volokhova, Apollinariya A.
Fedorishin, Dmitry A.
Khvastunova, Arina O.
Spiridonova, Tatiana I.
Kozelskaya, Anna I.
Kzhyshkowska, Julia
Tverdokhlebov, Sergei I.
Kurzina, Irina
Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release
title Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release
title_full Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release
title_fullStr Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release
title_full_unstemmed Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release
title_short Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release
title_sort reactive magnetron plasma modification of electrospun plla scaffolds with incorporated chloramphenicol for controlled drug release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839200/
https://www.ncbi.nlm.nih.gov/pubmed/35160362
http://dx.doi.org/10.3390/polym14030373
work_keys_str_mv AT volokhovaapollinariyaa reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease
AT fedorishindmitrya reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease
AT khvastunovaarinao reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease
AT spiridonovatatianai reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease
AT kozelskayaannai reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease
AT kzhyshkowskajulia reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease
AT tverdokhlebovsergeii reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease
AT kurzinairina reactivemagnetronplasmamodificationofelectrospunpllascaffoldswithincorporatedchloramphenicolforcontrolleddrugrelease