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Quantitative Determination of Unbound Piperacillin and Imipenem in Biological Material from Critically Ill Using Thin-Film Microextraction-Liquid Chromatography-Mass Spectrometry

β-Lactam antibiotics are most commonly used in the critically ill, but their effective dosing is challenging and may result in sub-therapeutic concentrations that can lead to therapy failure and even promote antimicrobial resistance. In this study, we present the analytical tool enabling specific an...

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Detalles Bibliográficos
Autores principales:	Włodarski, Robert, Żuchowska, Karolina, Filipiak, Wojciech
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839241/ https://www.ncbi.nlm.nih.gov/pubmed/35164191 http://dx.doi.org/10.3390/molecules27030926

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