Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions

An efficient and general method for the synthesis of 3-sulfenylindoles and 3-selenylindoles employing visible-light irradiation with graphene oxide as a promoter at room temperature has been achieved. The reaction features are high yields, simple operation, metal-free and iodine-free conditions, an...

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Detalles Bibliográficos
Autores principales: Huang, Qing, Peng, Xiangjun, Li, Hong, He, Haiping, Liu, Liangxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839487/
https://www.ncbi.nlm.nih.gov/pubmed/35164036
http://dx.doi.org/10.3390/molecules27030772
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author Huang, Qing
Peng, Xiangjun
Li, Hong
He, Haiping
Liu, Liangxian
author_facet Huang, Qing
Peng, Xiangjun
Li, Hong
He, Haiping
Liu, Liangxian
author_sort Huang, Qing
collection PubMed
description An efficient and general method for the synthesis of 3-sulfenylindoles and 3-selenylindoles employing visible-light irradiation with graphene oxide as a promoter at room temperature has been achieved. The reaction features are high yields, simple operation, metal-free and iodine-free conditions, an easy-to-handle oxidant, and gram-scalable synthesis. This simple protocol allows one to access a wide range of 3-arylthioindoles, 3-arylselenylindoles, and even 3-thiocyanatoindoles with good to excellent yields.
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spelling pubmed-88394872022-02-13 Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions Huang, Qing Peng, Xiangjun Li, Hong He, Haiping Liu, Liangxian Molecules Article An efficient and general method for the synthesis of 3-sulfenylindoles and 3-selenylindoles employing visible-light irradiation with graphene oxide as a promoter at room temperature has been achieved. The reaction features are high yields, simple operation, metal-free and iodine-free conditions, an easy-to-handle oxidant, and gram-scalable synthesis. This simple protocol allows one to access a wide range of 3-arylthioindoles, 3-arylselenylindoles, and even 3-thiocyanatoindoles with good to excellent yields. MDPI 2022-01-25 /pmc/articles/PMC8839487/ /pubmed/35164036 http://dx.doi.org/10.3390/molecules27030772 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Qing
Peng, Xiangjun
Li, Hong
He, Haiping
Liu, Liangxian
Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions
title Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions
title_full Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions
title_fullStr Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions
title_full_unstemmed Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions
title_short Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy under Transition-Metal-Free Conditions
title_sort visible-light-induced, graphene oxide-promoted c3-chalcogenylation of indoles strategy under transition-metal-free conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839487/
https://www.ncbi.nlm.nih.gov/pubmed/35164036
http://dx.doi.org/10.3390/molecules27030772
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