Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase

Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells, wherein seven compounds were observed to possess...

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Detalles Bibliográficos
Autores principales: Vishwanath, Divakar, Girimanchanaika, Swamy S., Dukanya, Dukanya, Rangappa, Shobith, Yang, Ji-Rui, Pandey, Vijay, Lobie, Peter E., Basappa, Basappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839658/
https://www.ncbi.nlm.nih.gov/pubmed/35163965
http://dx.doi.org/10.3390/molecules27030703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839658/
https://www.ncbi.nlm.nih.gov/pubmed/35163965
http://dx.doi.org/10.3390/molecules27030703

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