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Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions

Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes w...

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Detalles Bibliográficos
Autores principales: Xiao, Qian, Tong, Qing-Xiao, Zhong, Jian-Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839682/
https://www.ncbi.nlm.nih.gov/pubmed/35163886
http://dx.doi.org/10.3390/molecules27030619
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author Xiao, Qian
Tong, Qing-Xiao
Zhong, Jian-Ji
author_facet Xiao, Qian
Tong, Qing-Xiao
Zhong, Jian-Ji
author_sort Xiao, Qian
collection PubMed
description Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes with thiols, represents one of the most efficient and atom-economic approaches for the carbon-sulfur bonds construction. In traditional methodologies, harsh conditions such as stoichiometric reagents or a specialized UV photo-apparatus were necessary suffering from various disadvantages. In particular, visible-light photoredox catalysis has also been demonstrated to be a greener and milder protocol for the thiol-ene/yne reactions in recent years. Additionally, unprecedented advancements have been achieved in this area during the past decade. In this review, we will summarize the recent advances in visible-light photoredox catalyzed thiol-ene/yne reactions from 2015 to 2021. Synthetic strategies, substrate scope, and proposed reaction pathways are mainly discussed.
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spelling pubmed-88396822022-02-13 Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions Xiao, Qian Tong, Qing-Xiao Zhong, Jian-Ji Molecules Review Visible-light photoredox catalysis has been established as a popular and powerful tool for organic transformations owing to its inherent characterization of environmental friendliness and sustainability in the past decades. The thiol-ene/yne reactions, the direct hydrothiolation of alkenes/alkynes with thiols, represents one of the most efficient and atom-economic approaches for the carbon-sulfur bonds construction. In traditional methodologies, harsh conditions such as stoichiometric reagents or a specialized UV photo-apparatus were necessary suffering from various disadvantages. In particular, visible-light photoredox catalysis has also been demonstrated to be a greener and milder protocol for the thiol-ene/yne reactions in recent years. Additionally, unprecedented advancements have been achieved in this area during the past decade. In this review, we will summarize the recent advances in visible-light photoredox catalyzed thiol-ene/yne reactions from 2015 to 2021. Synthetic strategies, substrate scope, and proposed reaction pathways are mainly discussed. MDPI 2022-01-18 /pmc/articles/PMC8839682/ /pubmed/35163886 http://dx.doi.org/10.3390/molecules27030619 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xiao, Qian
Tong, Qing-Xiao
Zhong, Jian-Ji
Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
title Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
title_full Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
title_fullStr Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
title_full_unstemmed Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
title_short Recent Advances in Visible-Light Photoredox Catalysis for the Thiol-Ene/Yne Reactions
title_sort recent advances in visible-light photoredox catalysis for the thiol-ene/yne reactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839682/
https://www.ncbi.nlm.nih.gov/pubmed/35163886
http://dx.doi.org/10.3390/molecules27030619
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