Nanoparticle-Induced m(6)A RNA Modification: Detection Methods, Mechanisms and Applications

With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m(6)A (N(6)-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and essential biological processes, the relationship between nanoparticles and m(6)A RNA modification for the modulation of these events has attracted substantial research interest. However, there is limited knowledge regarding the relationship between nanoparticles and m(6)A RNA modification, but evidence is beginning to emerge. Therefore, a summary of these aspects from current research on nanoparticle-induced m(6)A RNA modification is timely and significant. In this review, we highlight the roles of m(6)A RNA modification in the bioimpacts of nanoparticles and thus elaborate on the mechanisms of nanoparticle-induced m(6)A RNA modification. We also summarize the dynamic regulation and biofunctions of m(6)A RNA modification. Moreover, we emphasize recent advances in the application perspective of nanoparticle-induced m(6)A RNA modification in medication and toxicity of nanoparticles to provide a potential method to facilitate the design of nanoparticles by deliberately tuning m(6)A RNA modification.