Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70

Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s due to the flexible and hydrophilic nature of...

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Detalles Bibliográficos
Autores principales: O’Connor, Suzanne, Le Bihan, Yann-Vaï, Westwood, Isaac M., Liu, Manjuan, Mak, Oi Wei, Zazeri, Gabriel, Povinelli, Ana P. R., Jones, Alan M., van Montfort, Rob, Reynisson, Jóhannes, Collins, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839746/
https://www.ncbi.nlm.nih.gov/pubmed/35164081
http://dx.doi.org/10.3390/molecules27030817

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