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Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study
Lactococcus lactis strain Plasma (LC-Plasma) is reported to have anti-viral effects via direct activation of plasmacytoid dendritic cells, which upregulate the production of type I and III interferons. A randomized, placebo-controlled, double-blind, parallel group study was designed for elementary s...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839753/ https://www.ncbi.nlm.nih.gov/pubmed/35276914 http://dx.doi.org/10.3390/nu14030552 |
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author | Thu, Nghiem Nguyet Mai, Truong Tuyet Trang, Tran Thị Thu Tuan, Nguyen Anh Quyen, Tran Chau Hanh, Nguyen Lien Hoan, Nguyen Huu Lan, Bui Thi Huong Hau, Phung Thi Tue, Ha Huy Dung, Truong Viet Tsuji, Ryohei Watanabe, Yuta Yamamoto, Naoki Kanauchi, Osamu |
author_facet | Thu, Nghiem Nguyet Mai, Truong Tuyet Trang, Tran Thị Thu Tuan, Nguyen Anh Quyen, Tran Chau Hanh, Nguyen Lien Hoan, Nguyen Huu Lan, Bui Thi Huong Hau, Phung Thi Tue, Ha Huy Dung, Truong Viet Tsuji, Ryohei Watanabe, Yuta Yamamoto, Naoki Kanauchi, Osamu |
author_sort | Thu, Nghiem Nguyet |
collection | PubMed |
description | Lactococcus lactis strain Plasma (LC-Plasma) is reported to have anti-viral effects via direct activation of plasmacytoid dendritic cells, which upregulate the production of type I and III interferons. A randomized, placebo-controlled, double-blind, parallel group study was designed for elementary schoolchildren, grades 1 to 3, in Vietnam. LC-Plasma or a control were administered to schoolchildren as a beverage (1.0 × 10(11) count LC-Plasma/day/person). The primary endpoint was to determine the efficacy of LC-Plasma in reducing the cumulative days absent from school due to upper respiratory disease (URID) and gastrointestinal disease (GID), and the secondary endpoint was to evaluate the potency of LC-Plasma on URID/GID symptoms and general well-being scores. LC-Plasma intake significantly reduced the cumulative days absent from school due to URID/GID (Odds ratio (OR) = 0.57, p = 0.004) and URID alone (OR = 0.56, p = 0.005); LC-Plasma also significantly reduced the number of cumulative fever positive days during the first 4 weeks of intervention (OR = 0.58, p = 0.001) and cumulative days with diarrhea during the last 4 weeks of the intervention period (OR = 0.78, p = 0.01). The number of positive general wellbeing days was significantly improved in the LC-Plasma group compared with the control throughout the intervention period (OR = 0.93, 0.93, p = 0.03, 0.04 in the first and last 4 weeks of the intervention, respectively). These data suggest that LC-Plasma seems to improve the health condition of elementary schoolchildren and reduces school absenteeism due to infectious disease, especially URID. |
format | Online Article Text |
id | pubmed-8839753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88397532022-02-13 Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study Thu, Nghiem Nguyet Mai, Truong Tuyet Trang, Tran Thị Thu Tuan, Nguyen Anh Quyen, Tran Chau Hanh, Nguyen Lien Hoan, Nguyen Huu Lan, Bui Thi Huong Hau, Phung Thi Tue, Ha Huy Dung, Truong Viet Tsuji, Ryohei Watanabe, Yuta Yamamoto, Naoki Kanauchi, Osamu Nutrients Article Lactococcus lactis strain Plasma (LC-Plasma) is reported to have anti-viral effects via direct activation of plasmacytoid dendritic cells, which upregulate the production of type I and III interferons. A randomized, placebo-controlled, double-blind, parallel group study was designed for elementary schoolchildren, grades 1 to 3, in Vietnam. LC-Plasma or a control were administered to schoolchildren as a beverage (1.0 × 10(11) count LC-Plasma/day/person). The primary endpoint was to determine the efficacy of LC-Plasma in reducing the cumulative days absent from school due to upper respiratory disease (URID) and gastrointestinal disease (GID), and the secondary endpoint was to evaluate the potency of LC-Plasma on URID/GID symptoms and general well-being scores. LC-Plasma intake significantly reduced the cumulative days absent from school due to URID/GID (Odds ratio (OR) = 0.57, p = 0.004) and URID alone (OR = 0.56, p = 0.005); LC-Plasma also significantly reduced the number of cumulative fever positive days during the first 4 weeks of intervention (OR = 0.58, p = 0.001) and cumulative days with diarrhea during the last 4 weeks of the intervention period (OR = 0.78, p = 0.01). The number of positive general wellbeing days was significantly improved in the LC-Plasma group compared with the control throughout the intervention period (OR = 0.93, 0.93, p = 0.03, 0.04 in the first and last 4 weeks of the intervention, respectively). These data suggest that LC-Plasma seems to improve the health condition of elementary schoolchildren and reduces school absenteeism due to infectious disease, especially URID. MDPI 2022-01-27 /pmc/articles/PMC8839753/ /pubmed/35276914 http://dx.doi.org/10.3390/nu14030552 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Thu, Nghiem Nguyet Mai, Truong Tuyet Trang, Tran Thị Thu Tuan, Nguyen Anh Quyen, Tran Chau Hanh, Nguyen Lien Hoan, Nguyen Huu Lan, Bui Thi Huong Hau, Phung Thi Tue, Ha Huy Dung, Truong Viet Tsuji, Ryohei Watanabe, Yuta Yamamoto, Naoki Kanauchi, Osamu Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study |
title | Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study |
title_full | Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study |
title_fullStr | Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study |
title_full_unstemmed | Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study |
title_short | Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study |
title_sort | impact of infectious disease after lactococcus lactis strain plasma intake in vietnamese schoolchildren: a randomized, placebo-controlled, double-blind study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839753/ https://www.ncbi.nlm.nih.gov/pubmed/35276914 http://dx.doi.org/10.3390/nu14030552 |
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