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Creatine as a Promising Component of Paternal Preconception Diet
Male fertility has been declining globally over the past several decades, advancing from a personal issue to a public health problem. Beyond any doubt, a reduction in fertility (often characterized by low sperm count or motility) can severely threaten reproductive health and lifecourse framework in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839819/ https://www.ncbi.nlm.nih.gov/pubmed/35276945 http://dx.doi.org/10.3390/nu14030586 |
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author | Ostojic, Sergej M. Stea, Tonje Holte Engeset, Dagrun |
author_facet | Ostojic, Sergej M. Stea, Tonje Holte Engeset, Dagrun |
author_sort | Ostojic, Sergej M. |
collection | PubMed |
description | Male fertility has been declining globally over the past several decades, advancing from a personal issue to a public health problem. Beyond any doubt, a reduction in fertility (often characterized by low sperm count or motility) can severely threaten reproductive health and lifecourse framework in a long-term fashion. Aside from uncovering the currently unknown etiology of modern-day male infertility, the scientific and medical community faces a double burden: finding an efficient biomarker of impaired fertility and exploring any intervention that can act to enhance fertility. A plethora of nutritional compounds have been recognized as possible modulators of semen quality, and specific dietary patterns and nutrients appear to be accompanied by a lower risk of male infertility. Creatine, a conditionally essential nutrient, has caught attention as a male fertility-promoting candidate due to its role in sperm energy metabolism. This mini-review describes the creatine-related bioenergetics of spermatozoa, explores a connection between creatine levels and sperm quality in men, and critically examines available evidence for interventional studies with creatine to affect sperm viability. |
format | Online Article Text |
id | pubmed-8839819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88398192022-02-13 Creatine as a Promising Component of Paternal Preconception Diet Ostojic, Sergej M. Stea, Tonje Holte Engeset, Dagrun Nutrients Review Male fertility has been declining globally over the past several decades, advancing from a personal issue to a public health problem. Beyond any doubt, a reduction in fertility (often characterized by low sperm count or motility) can severely threaten reproductive health and lifecourse framework in a long-term fashion. Aside from uncovering the currently unknown etiology of modern-day male infertility, the scientific and medical community faces a double burden: finding an efficient biomarker of impaired fertility and exploring any intervention that can act to enhance fertility. A plethora of nutritional compounds have been recognized as possible modulators of semen quality, and specific dietary patterns and nutrients appear to be accompanied by a lower risk of male infertility. Creatine, a conditionally essential nutrient, has caught attention as a male fertility-promoting candidate due to its role in sperm energy metabolism. This mini-review describes the creatine-related bioenergetics of spermatozoa, explores a connection between creatine levels and sperm quality in men, and critically examines available evidence for interventional studies with creatine to affect sperm viability. MDPI 2022-01-28 /pmc/articles/PMC8839819/ /pubmed/35276945 http://dx.doi.org/10.3390/nu14030586 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ostojic, Sergej M. Stea, Tonje Holte Engeset, Dagrun Creatine as a Promising Component of Paternal Preconception Diet |
title | Creatine as a Promising Component of Paternal Preconception Diet |
title_full | Creatine as a Promising Component of Paternal Preconception Diet |
title_fullStr | Creatine as a Promising Component of Paternal Preconception Diet |
title_full_unstemmed | Creatine as a Promising Component of Paternal Preconception Diet |
title_short | Creatine as a Promising Component of Paternal Preconception Diet |
title_sort | creatine as a promising component of paternal preconception diet |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839819/ https://www.ncbi.nlm.nih.gov/pubmed/35276945 http://dx.doi.org/10.3390/nu14030586 |
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