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The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity

Allium species and their organosulfur-derived compounds could prevent obesity and metabolic dysfunction, as they exhibit immunomodulatory and antimicrobial properties. Here, we report the anti-obesogenic potential and dose-dependent effects (0.1 or 1 mg/kg/day) of propyl propane thiosulfinate (PTS)...

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Autores principales: Liébana-García, Rebeca, Olivares, Marta, Rodríguez-Ruano, Sonia M., Tolosa-Enguís, Verónica, Chulia, Isabel, Gil-Martínez, Lidia, Guillamón, Enrique, Baños, Alberto, Sanz, Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839906/
https://www.ncbi.nlm.nih.gov/pubmed/35276798
http://dx.doi.org/10.3390/nu14030440
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author Liébana-García, Rebeca
Olivares, Marta
Rodríguez-Ruano, Sonia M.
Tolosa-Enguís, Verónica
Chulia, Isabel
Gil-Martínez, Lidia
Guillamón, Enrique
Baños, Alberto
Sanz, Yolanda
author_facet Liébana-García, Rebeca
Olivares, Marta
Rodríguez-Ruano, Sonia M.
Tolosa-Enguís, Verónica
Chulia, Isabel
Gil-Martínez, Lidia
Guillamón, Enrique
Baños, Alberto
Sanz, Yolanda
author_sort Liébana-García, Rebeca
collection PubMed
description Allium species and their organosulfur-derived compounds could prevent obesity and metabolic dysfunction, as they exhibit immunomodulatory and antimicrobial properties. Here, we report the anti-obesogenic potential and dose-dependent effects (0.1 or 1 mg/kg/day) of propyl propane thiosulfinate (PTS) in a murine model of diet-induced obesity. The obesogenic diet increased body weight gain and adipocyte size, and boosted inflammatory marker (Cd11c) expression in the adipose tissue. Conversely, PTS prevented these effects in a dose-dependent manner. Moreover, the higher dose of PTS improved glucose and hepatic homeostasis, modulated lipid metabolism, and raised markers of the thermogenic capacity of brown adipose tissue. In the colon, the obesogenic diet reduced IL-22 levels and increased gut barrier function markers (Cldn3, Muc2, Reg3g, DefaA); however, the highest PTS dose normalized all of these markers to the levels of mice fed a standard diet. Gut microbiota analyses revealed no differences in diversity indexes and only minor taxonomic changes, such as an increase in butyrate producers, Intestimonas and Alistipes, and a decrease in Bifidobacterium in mice receiving the highest PTS dose. In summary, our study provides preclinical evidence for the protective effects of PTS against obesity, which if confirmed in humans, might provide a novel plant-based dietary product to counteract this condition.
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spelling pubmed-88399062022-02-13 The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity Liébana-García, Rebeca Olivares, Marta Rodríguez-Ruano, Sonia M. Tolosa-Enguís, Verónica Chulia, Isabel Gil-Martínez, Lidia Guillamón, Enrique Baños, Alberto Sanz, Yolanda Nutrients Article Allium species and their organosulfur-derived compounds could prevent obesity and metabolic dysfunction, as they exhibit immunomodulatory and antimicrobial properties. Here, we report the anti-obesogenic potential and dose-dependent effects (0.1 or 1 mg/kg/day) of propyl propane thiosulfinate (PTS) in a murine model of diet-induced obesity. The obesogenic diet increased body weight gain and adipocyte size, and boosted inflammatory marker (Cd11c) expression in the adipose tissue. Conversely, PTS prevented these effects in a dose-dependent manner. Moreover, the higher dose of PTS improved glucose and hepatic homeostasis, modulated lipid metabolism, and raised markers of the thermogenic capacity of brown adipose tissue. In the colon, the obesogenic diet reduced IL-22 levels and increased gut barrier function markers (Cldn3, Muc2, Reg3g, DefaA); however, the highest PTS dose normalized all of these markers to the levels of mice fed a standard diet. Gut microbiota analyses revealed no differences in diversity indexes and only minor taxonomic changes, such as an increase in butyrate producers, Intestimonas and Alistipes, and a decrease in Bifidobacterium in mice receiving the highest PTS dose. In summary, our study provides preclinical evidence for the protective effects of PTS against obesity, which if confirmed in humans, might provide a novel plant-based dietary product to counteract this condition. MDPI 2022-01-19 /pmc/articles/PMC8839906/ /pubmed/35276798 http://dx.doi.org/10.3390/nu14030440 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liébana-García, Rebeca
Olivares, Marta
Rodríguez-Ruano, Sonia M.
Tolosa-Enguís, Verónica
Chulia, Isabel
Gil-Martínez, Lidia
Guillamón, Enrique
Baños, Alberto
Sanz, Yolanda
The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity
title The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity
title_full The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity
title_fullStr The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity
title_full_unstemmed The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity
title_short The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity
title_sort allium derivate propyl propane thiosulfinate exerts anti-obesogenic effects in a murine model of diet-induced obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839906/
https://www.ncbi.nlm.nih.gov/pubmed/35276798
http://dx.doi.org/10.3390/nu14030440
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