Hf(OTf)(4)-Catalyzed Three-Component Synthesis of N-Carbamate-Protected β-Amino Ketones

Hafnium(IV) triflate (Hf(OTf)(4)) has been identified as a potent catalyst for the direct three-component synthesis of β-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected...

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Detalles Bibliográficos
Autores principales: Chen, Zhen-Zhen, Yang, Dong-Zhao, Dong, Ying-Ying, Chi, Mei, Pu, Shou-Zhi, Sun, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840004/
https://www.ncbi.nlm.nih.gov/pubmed/35164390
http://dx.doi.org/10.3390/molecules27031122
Descripción
Sumario:Hafnium(IV) triflate (Hf(OTf)(4)) has been identified as a potent catalyst for the direct three-component synthesis of β-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected Mannich bases. A mechanistic investigation indicated that the three-component reaction proceeds via sequential aldol condensation and aza-Michael addition, but not the Mannich-type pathway.

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