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Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration

Adsorption of urea from dialysate is essential for wearable artificial kidneys (WRK). Molecularly imprinted microspheres with nanoporous and multilayered structures are prepared based on liquid–liquid phase separation (LLPS), which can selectively adsorb urea. In addition, we combine the microsphere...

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Detalles Bibliográficos
Autores principales: Wu, Hongchi, Zhang, Shanguo, Liu, Lu, Ren, Yukun, Xue, Chun, Wu, Wenlong, Chen, Xiaoming, Jiang, Hongyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840109/
https://www.ncbi.nlm.nih.gov/pubmed/35159766
http://dx.doi.org/10.3390/nano12030418
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author Wu, Hongchi
Zhang, Shanguo
Liu, Lu
Ren, Yukun
Xue, Chun
Wu, Wenlong
Chen, Xiaoming
Jiang, Hongyuan
author_facet Wu, Hongchi
Zhang, Shanguo
Liu, Lu
Ren, Yukun
Xue, Chun
Wu, Wenlong
Chen, Xiaoming
Jiang, Hongyuan
author_sort Wu, Hongchi
collection PubMed
description Adsorption of urea from dialysate is essential for wearable artificial kidneys (WRK). Molecularly imprinted microspheres with nanoporous and multilayered structures are prepared based on liquid–liquid phase separation (LLPS), which can selectively adsorb urea. In addition, we combine the microspheres with a designed polydimethylsiloxane (PDMS) chip to propose an efficient urea adsorption platform. In this work, we propose a formulation of LLPS including Tripropylene glycol diacrylate (TPGDA), ethanol, and acrylic acid (30% v/v), to prepare urea molecularly imprinted microspheres in a simple and highly controllable method. These microspheres have urea molecular imprinting sites on the surface and inside, allowing selective adsorption of urea and preservation of other essential constituents. Previous static studies on urea adsorption have not considered the combination between urea adsorbent and WRK. Therefore, we design the platform embedded with urea molecular imprinted microspheres, which can disturb the fluid motion and improve the efficiency of urea adsorption. These advantages enable the urea absorption platform to be highly promising for dialysate regeneration in WRK.
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spelling pubmed-88401092022-02-13 Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration Wu, Hongchi Zhang, Shanguo Liu, Lu Ren, Yukun Xue, Chun Wu, Wenlong Chen, Xiaoming Jiang, Hongyuan Nanomaterials (Basel) Article Adsorption of urea from dialysate is essential for wearable artificial kidneys (WRK). Molecularly imprinted microspheres with nanoporous and multilayered structures are prepared based on liquid–liquid phase separation (LLPS), which can selectively adsorb urea. In addition, we combine the microspheres with a designed polydimethylsiloxane (PDMS) chip to propose an efficient urea adsorption platform. In this work, we propose a formulation of LLPS including Tripropylene glycol diacrylate (TPGDA), ethanol, and acrylic acid (30% v/v), to prepare urea molecularly imprinted microspheres in a simple and highly controllable method. These microspheres have urea molecular imprinting sites on the surface and inside, allowing selective adsorption of urea and preservation of other essential constituents. Previous static studies on urea adsorption have not considered the combination between urea adsorbent and WRK. Therefore, we design the platform embedded with urea molecular imprinted microspheres, which can disturb the fluid motion and improve the efficiency of urea adsorption. These advantages enable the urea absorption platform to be highly promising for dialysate regeneration in WRK. MDPI 2022-01-27 /pmc/articles/PMC8840109/ /pubmed/35159766 http://dx.doi.org/10.3390/nano12030418 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Hongchi
Zhang, Shanguo
Liu, Lu
Ren, Yukun
Xue, Chun
Wu, Wenlong
Chen, Xiaoming
Jiang, Hongyuan
Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration
title Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration
title_full Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration
title_fullStr Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration
title_full_unstemmed Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration
title_short Controllable Fabrication of Molecularly Imprinted Microspheres with Nanoporous and Multilayered Structure for Dialysate Regeneration
title_sort controllable fabrication of molecularly imprinted microspheres with nanoporous and multilayered structure for dialysate regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840109/
https://www.ncbi.nlm.nih.gov/pubmed/35159766
http://dx.doi.org/10.3390/nano12030418
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