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Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq

Chlorophytum genus has been extensively studied due to its diverse biological activities. We evaluated the methanolic extract of leaves of Chlorophytum comosum (Green type) (Thunb.) Jacques, the species that is less studied compared to C. borivilianum. The aim was to identify phytoconstituents of th...

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Autores principales: Rzhepakovsky, Igor V., Areshidze, David A., Avanesyan, Svetlana S., Grimm, Wolf D., Filatova, Natalya V., Kalinin, Aleksander V., Kochergin, Stanislav G., Kozlova, Maria A., Kurchenko, Vladimir P., Sizonenko, Marina N., Terentiev, Alexei A., Timchenko, Lyudmila D., Trigub, Maria M., Nagdalian, Andrey A., Piskov, Sergei I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840168/
https://www.ncbi.nlm.nih.gov/pubmed/35164026
http://dx.doi.org/10.3390/molecules27030762
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author Rzhepakovsky, Igor V.
Areshidze, David A.
Avanesyan, Svetlana S.
Grimm, Wolf D.
Filatova, Natalya V.
Kalinin, Aleksander V.
Kochergin, Stanislav G.
Kozlova, Maria A.
Kurchenko, Vladimir P.
Sizonenko, Marina N.
Terentiev, Alexei A.
Timchenko, Lyudmila D.
Trigub, Maria M.
Nagdalian, Andrey A.
Piskov, Sergei I.
author_facet Rzhepakovsky, Igor V.
Areshidze, David A.
Avanesyan, Svetlana S.
Grimm, Wolf D.
Filatova, Natalya V.
Kalinin, Aleksander V.
Kochergin, Stanislav G.
Kozlova, Maria A.
Kurchenko, Vladimir P.
Sizonenko, Marina N.
Terentiev, Alexei A.
Timchenko, Lyudmila D.
Trigub, Maria M.
Nagdalian, Andrey A.
Piskov, Sergei I.
author_sort Rzhepakovsky, Igor V.
collection PubMed
description Chlorophytum genus has been extensively studied due to its diverse biological activities. We evaluated the methanolic extract of leaves of Chlorophytum comosum (Green type) (Thunb.) Jacques, the species that is less studied compared to C. borivilianum. The aim was to identify phytoconstituents of the methanolic extract of leaves of C. comosum and biological properties of its different fractions. Water fraction was analyzed with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Nineteen compounds belonging to different chemical classes were identified in the methanolic extract of leaves of C. comosum (Green type) (Thunb.) Jacques. In addition to several fatty acids, isoprenoid and steroid compounds were found among the most abundant constituents. One of the identified compounds, 4′-methylphenyl-1C-sulfonyl-β-d-galactoside, was not detected earlier in Chlorophytum extracts. The water fraction was toxic to HeLa cells but not to Vero cells. Our data demonstrate that methanolic extract of leaves of C. comosum can be a valuable source of bioactive constituents. The water fraction of the extract exhibited promising antitumor potential based on a high ratio of HeLa vs. Vero cytotoxicity.
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spelling pubmed-88401682022-02-13 Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq Rzhepakovsky, Igor V. Areshidze, David A. Avanesyan, Svetlana S. Grimm, Wolf D. Filatova, Natalya V. Kalinin, Aleksander V. Kochergin, Stanislav G. Kozlova, Maria A. Kurchenko, Vladimir P. Sizonenko, Marina N. Terentiev, Alexei A. Timchenko, Lyudmila D. Trigub, Maria M. Nagdalian, Andrey A. Piskov, Sergei I. Molecules Article Chlorophytum genus has been extensively studied due to its diverse biological activities. We evaluated the methanolic extract of leaves of Chlorophytum comosum (Green type) (Thunb.) Jacques, the species that is less studied compared to C. borivilianum. The aim was to identify phytoconstituents of the methanolic extract of leaves of C. comosum and biological properties of its different fractions. Water fraction was analyzed with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Nineteen compounds belonging to different chemical classes were identified in the methanolic extract of leaves of C. comosum (Green type) (Thunb.) Jacques. In addition to several fatty acids, isoprenoid and steroid compounds were found among the most abundant constituents. One of the identified compounds, 4′-methylphenyl-1C-sulfonyl-β-d-galactoside, was not detected earlier in Chlorophytum extracts. The water fraction was toxic to HeLa cells but not to Vero cells. Our data demonstrate that methanolic extract of leaves of C. comosum can be a valuable source of bioactive constituents. The water fraction of the extract exhibited promising antitumor potential based on a high ratio of HeLa vs. Vero cytotoxicity. MDPI 2022-01-24 /pmc/articles/PMC8840168/ /pubmed/35164026 http://dx.doi.org/10.3390/molecules27030762 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rzhepakovsky, Igor V.
Areshidze, David A.
Avanesyan, Svetlana S.
Grimm, Wolf D.
Filatova, Natalya V.
Kalinin, Aleksander V.
Kochergin, Stanislav G.
Kozlova, Maria A.
Kurchenko, Vladimir P.
Sizonenko, Marina N.
Terentiev, Alexei A.
Timchenko, Lyudmila D.
Trigub, Maria M.
Nagdalian, Andrey A.
Piskov, Sergei I.
Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq
title Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq
title_full Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq
title_fullStr Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq
title_full_unstemmed Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq
title_short Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq
title_sort phytochemical characterization, antioxidant activity, and cytotoxicity of methanolic leaf extract of chlorophytum comosum (green type) (thunb.) jacq
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840168/
https://www.ncbi.nlm.nih.gov/pubmed/35164026
http://dx.doi.org/10.3390/molecules27030762
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