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Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice

Pancreatitis has been implicated in the development and progression of type 2 diabetes and cancer. The pancreas uptakes molecular iodine (I(2)), which has anti-inflammatory and antioxidant effects. The present work analyzes whether oral I(2) supplementation prevents the pancreatic alterations promot...

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Autores principales: Rodríguez-Castelán, Julia, Delgado-González, Evangelina, Varela-Floriano, Valentin, Anguiano, Brenda, Aceves, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840345/
https://www.ncbi.nlm.nih.gov/pubmed/35277074
http://dx.doi.org/10.3390/nu14030715
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author Rodríguez-Castelán, Julia
Delgado-González, Evangelina
Varela-Floriano, Valentin
Anguiano, Brenda
Aceves, Carmen
author_facet Rodríguez-Castelán, Julia
Delgado-González, Evangelina
Varela-Floriano, Valentin
Anguiano, Brenda
Aceves, Carmen
author_sort Rodríguez-Castelán, Julia
collection PubMed
description Pancreatitis has been implicated in the development and progression of type 2 diabetes and cancer. The pancreas uptakes molecular iodine (I(2)), which has anti-inflammatory and antioxidant effects. The present work analyzes whether oral I(2) supplementation prevents the pancreatic alterations promoted by low doses of streptozotocin (STZ). CD1 mice (12 weeks old) were divided into the following groups: control; STZ (20 mg/kg/day, i.p. for five days); I(2) (0.2 mg/Kg/day in drinking water for 15 days); and combined (STZ + I(2)). Inflammation (Masson’s trichrome and periodic acid–Schiff stain), hyperglycemia, decreased β-cells and increased α-cells in pancreas were observed in male and female animals with STZ. These animals also showed pancreatic increases in immune cells and inflammation markers as tumor necrosis factor-alpha, transforming growth factor-beta and inducible nitric oxide synthase with a higher amount of activated pancreatic stellate cells (PSCs). The I(2) supplement prevented the harmful effect of STZ, maintaining normal pancreatic morphometry and functions. The elevation of the nuclear factor erythroid-2 (Nrf2) and peroxisome proliferator-activated receptor type gamma (PPARγ) contents was associated with the preservation of normal glycemia and lipoperoxidation. In conclusion, a moderated supplement of I(2) prevents the deleterious effects of STZ in the pancreas, possibly through antioxidant and antifibrotic mechanisms including Nrf2 and PPARγ activation.
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spelling pubmed-88403452022-02-13 Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice Rodríguez-Castelán, Julia Delgado-González, Evangelina Varela-Floriano, Valentin Anguiano, Brenda Aceves, Carmen Nutrients Article Pancreatitis has been implicated in the development and progression of type 2 diabetes and cancer. The pancreas uptakes molecular iodine (I(2)), which has anti-inflammatory and antioxidant effects. The present work analyzes whether oral I(2) supplementation prevents the pancreatic alterations promoted by low doses of streptozotocin (STZ). CD1 mice (12 weeks old) were divided into the following groups: control; STZ (20 mg/kg/day, i.p. for five days); I(2) (0.2 mg/Kg/day in drinking water for 15 days); and combined (STZ + I(2)). Inflammation (Masson’s trichrome and periodic acid–Schiff stain), hyperglycemia, decreased β-cells and increased α-cells in pancreas were observed in male and female animals with STZ. These animals also showed pancreatic increases in immune cells and inflammation markers as tumor necrosis factor-alpha, transforming growth factor-beta and inducible nitric oxide synthase with a higher amount of activated pancreatic stellate cells (PSCs). The I(2) supplement prevented the harmful effect of STZ, maintaining normal pancreatic morphometry and functions. The elevation of the nuclear factor erythroid-2 (Nrf2) and peroxisome proliferator-activated receptor type gamma (PPARγ) contents was associated with the preservation of normal glycemia and lipoperoxidation. In conclusion, a moderated supplement of I(2) prevents the deleterious effects of STZ in the pancreas, possibly through antioxidant and antifibrotic mechanisms including Nrf2 and PPARγ activation. MDPI 2022-02-08 /pmc/articles/PMC8840345/ /pubmed/35277074 http://dx.doi.org/10.3390/nu14030715 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodríguez-Castelán, Julia
Delgado-González, Evangelina
Varela-Floriano, Valentin
Anguiano, Brenda
Aceves, Carmen
Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice
title Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice
title_full Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice
title_fullStr Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice
title_full_unstemmed Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice
title_short Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice
title_sort molecular iodine supplement prevents streptozotocin-induced pancreatic alterations in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840345/
https://www.ncbi.nlm.nih.gov/pubmed/35277074
http://dx.doi.org/10.3390/nu14030715
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