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Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides

Hypoxia in tumors results in resistance to both chemotherapy and radiotherapy treatments but affords an environment in which hypoxia-activated prodrugs (HAP) are activated upon bioreduction to release targeted cytotoxins. The benzotriazine 1,4-di-N-oxide (BTO) HAP, tirapazamine (TPZ, 1), has undergo...

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Detalles Bibliográficos
Autores principales:	Qi, Wen, Yadav, Pooja, Hong, Cho R., Stevenson, Ralph J., Hay, Michael P., Anderson, Robert F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840461/ https://www.ncbi.nlm.nih.gov/pubmed/35164077 http://dx.doi.org/10.3390/molecules27030812

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