Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway

Four new benzoylamide derivatives, lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalum Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccha...

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Autores principales: Li, Meng, Zhang, Beibei, Zeng, Mengnan, Zhang, Jingke, Zhang, Zhiguang, Feng, Weisheng, Zheng, Xiaoke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840667/
https://www.ncbi.nlm.nih.gov/pubmed/35163986
http://dx.doi.org/10.3390/molecules27030722
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author Li, Meng
Zhang, Beibei
Zeng, Mengnan
Zhang, Jingke
Zhang, Zhiguang
Feng, Weisheng
Zheng, Xiaoke
author_facet Li, Meng
Zhang, Beibei
Zeng, Mengnan
Zhang, Jingke
Zhang, Zhiguang
Feng, Weisheng
Zheng, Xiaoke
author_sort Li, Meng
collection PubMed
description Four new benzoylamide derivatives, lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalum Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury.
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spelling pubmed-88406672022-02-13 Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway Li, Meng Zhang, Beibei Zeng, Mengnan Zhang, Jingke Zhang, Zhiguang Feng, Weisheng Zheng, Xiaoke Molecules Article Four new benzoylamide derivatives, lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalum Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury. MDPI 2022-01-22 /pmc/articles/PMC8840667/ /pubmed/35163986 http://dx.doi.org/10.3390/molecules27030722 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Meng
Zhang, Beibei
Zeng, Mengnan
Zhang, Jingke
Zhang, Zhiguang
Feng, Weisheng
Zheng, Xiaoke
Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
title Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
title_full Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
title_fullStr Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
title_full_unstemmed Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
title_short Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
title_sort four new benzoylamide derivatives isolated from the seeds of lepidium apetalum willd. and ameliorated lps-induced nrk52e cells via nrf2/keap1 pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840667/
https://www.ncbi.nlm.nih.gov/pubmed/35163986
http://dx.doi.org/10.3390/molecules27030722
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