PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders

Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in PSTPIP1 F-BAR domain, which binds to LYP, a protein tyrosine phosphatase associated with a...

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Detalles Bibliográficos
Autores principales: Manso, José A., Marcos, Tamara, Ruiz-Martín, Virginia, Casas, Javier, Alcón, Pablo, Sánchez Crespo, Mariano, Bayón, Yolanda, de Pereda, José M., Alonso, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840930/
https://www.ncbi.nlm.nih.gov/pubmed/35152348
http://dx.doi.org/10.1007/s00018-022-04173-w

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