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Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study

BACKGROUND: Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress and uric acid (UA) has strong antioxidant properties. The aim of this study was to investigate the relationship between UA and sarcopenia in comm...

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Autores principales: Liu, Xiaolei, Chen, Xiaoyan, Hu, Fengjuan, Xia, Xin, Hou, Lisha, Zhang, Gongchang, Peng, Xuchao, Sun, Xuelian, Luo, Shuyue, Yue, Jirong, Dong, Birong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841067/
https://www.ncbi.nlm.nih.gov/pubmed/35151263
http://dx.doi.org/10.1186/s12877-022-02817-x
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author Liu, Xiaolei
Chen, Xiaoyan
Hu, Fengjuan
Xia, Xin
Hou, Lisha
Zhang, Gongchang
Peng, Xuchao
Sun, Xuelian
Luo, Shuyue
Yue, Jirong
Dong, Birong
author_facet Liu, Xiaolei
Chen, Xiaoyan
Hu, Fengjuan
Xia, Xin
Hou, Lisha
Zhang, Gongchang
Peng, Xuchao
Sun, Xuelian
Luo, Shuyue
Yue, Jirong
Dong, Birong
author_sort Liu, Xiaolei
collection PubMed
description BACKGROUND: Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress and uric acid (UA) has strong antioxidant properties. The aim of this study was to investigate the relationship between UA and sarcopenia in community-dwelling adults of West China using the baseline data of West China Health and Aging Trend (WCHAT) study. DESIGN: A cross-sectional study. METHODS: 4236 adults aged 50 years or older in communities of west China were enrolled in this study. We applied Asian Working Group for Sarcopenia (AWGS) 2019 criteria to define sarcopenia. Muscle mass was measured using skeletal muscle index (SMI) based on bioimpedance analysis (BIA). Handgrip strength (HGS) and gait speed (GS) were recorded, respectively. Different variables like anthropometry measures, life styles, chronic disease and blood test were collected. General linear model was done to investigate the relationship between UA and HGS/GS/SMI, adjusting age, ethnic groups, sleeping quality, education level, cognitive function, smoking history, drinking history, ADL score, and chronic disease. RESULTS: Participants were grouped according to UA quartiles by gender. After adjusting for potential confounders, a negative association between serum UA levels and sarcopenia was shown both in men and women. And a significant association between serum UA levels and HGS in women was shown as an inverted J shape. Besides, a positive association between the UA quartiles and SMI was observed, irrespective of gender. CONCLUSIONS: Our results showed that higher uric acid levels were significantly correlated with higher muscle mass and grip strength among Chinese adults aged over 50. Higher UA serum levels might slow down the progression of sarcopenia.
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spelling pubmed-88410672022-02-16 Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study Liu, Xiaolei Chen, Xiaoyan Hu, Fengjuan Xia, Xin Hou, Lisha Zhang, Gongchang Peng, Xuchao Sun, Xuelian Luo, Shuyue Yue, Jirong Dong, Birong BMC Geriatr Research BACKGROUND: Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress and uric acid (UA) has strong antioxidant properties. The aim of this study was to investigate the relationship between UA and sarcopenia in community-dwelling adults of West China using the baseline data of West China Health and Aging Trend (WCHAT) study. DESIGN: A cross-sectional study. METHODS: 4236 adults aged 50 years or older in communities of west China were enrolled in this study. We applied Asian Working Group for Sarcopenia (AWGS) 2019 criteria to define sarcopenia. Muscle mass was measured using skeletal muscle index (SMI) based on bioimpedance analysis (BIA). Handgrip strength (HGS) and gait speed (GS) were recorded, respectively. Different variables like anthropometry measures, life styles, chronic disease and blood test were collected. General linear model was done to investigate the relationship between UA and HGS/GS/SMI, adjusting age, ethnic groups, sleeping quality, education level, cognitive function, smoking history, drinking history, ADL score, and chronic disease. RESULTS: Participants were grouped according to UA quartiles by gender. After adjusting for potential confounders, a negative association between serum UA levels and sarcopenia was shown both in men and women. And a significant association between serum UA levels and HGS in women was shown as an inverted J shape. Besides, a positive association between the UA quartiles and SMI was observed, irrespective of gender. CONCLUSIONS: Our results showed that higher uric acid levels were significantly correlated with higher muscle mass and grip strength among Chinese adults aged over 50. Higher UA serum levels might slow down the progression of sarcopenia. BioMed Central 2022-02-12 /pmc/articles/PMC8841067/ /pubmed/35151263 http://dx.doi.org/10.1186/s12877-022-02817-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Xiaolei
Chen, Xiaoyan
Hu, Fengjuan
Xia, Xin
Hou, Lisha
Zhang, Gongchang
Peng, Xuchao
Sun, Xuelian
Luo, Shuyue
Yue, Jirong
Dong, Birong
Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study
title Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study
title_full Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study
title_fullStr Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study
title_full_unstemmed Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study
title_short Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study
title_sort higher uric acid serum levels are associated with sarcopenia in west china: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841067/
https://www.ncbi.nlm.nih.gov/pubmed/35151263
http://dx.doi.org/10.1186/s12877-022-02817-x
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