Gene-Interaction-Sensitive enrichment analysis in congenital heart disease

BACKGROUND: Gene set enrichment analysis (GSEA) uses gene-level univariate associations to identify gene set-phenotype associations for hypothesis generation and interpretation. We propose that GSEA can be adapted to incorporate SNP and gene-level interactions. To this end, gene scores are derived b...

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Detalles Bibliográficos
Autores principales: Woodward, Alexa A., Taylor, Deanne M., Goldmuntz, Elizabeth, Mitchell, Laura E., Agopian, A.J., Moore, Jason H., Urbanowicz, Ryan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841104/
https://www.ncbi.nlm.nih.gov/pubmed/35151364
http://dx.doi.org/10.1186/s13040-022-00287-w

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