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Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis

BACKGROUND: This study investigated whether the discordance between erythrocyte sedimentation rate (ESR) and C‐reactive protein at diagnosis could estimate the simultaneous clinical and laboratory variables and predict the poor outcomes during follow‐up in patients with antineutrophil cytoplasmic an...

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Autores principales: Park, Pil Gyu, Song, Jason Jungsik, Park, Yong‐Beom, Lee, Sang‐Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841132/
https://www.ncbi.nlm.nih.gov/pubmed/34997790
http://dx.doi.org/10.1002/jcla.24237
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author Park, Pil Gyu
Song, Jason Jungsik
Park, Yong‐Beom
Lee, Sang‐Won
author_facet Park, Pil Gyu
Song, Jason Jungsik
Park, Yong‐Beom
Lee, Sang‐Won
author_sort Park, Pil Gyu
collection PubMed
description BACKGROUND: This study investigated whether the discordance between erythrocyte sedimentation rate (ESR) and C‐reactive protein at diagnosis could estimate the simultaneous clinical and laboratory variables and predict the poor outcomes during follow‐up in patients with antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). METHODS: The medical records of 254 AAV patients were reviewed. Clinical and laboratory and AAV‐specific indices at diagnosis and all‐cause mortality, relapse and end‐stage renal disease during follow‐up were obtained. ESR and CRP levels were categorised as high and low based on the median values. Accordingly, the patients were divided into the following four groups: high ESR/low CRP; low ESR/high CRP; low ESR/low CRP; and high ESR/high CRP. RESULTS: Of the 254 AAV patients, 51 patients exhibited discordance between ESR and CRP. Among the 51 AAV patients, the median age was 59.0 years, and 20 patients were men (29 MPA, 13 GPA and 9 EGPA). Cardiovascular and nervous systemic manifestations were observed more frequently in AAV patients with low ESR/high CRP than in those with high ESR/low CRP. Six patients from the low ESR/high CRP group died. AAV patients with low ESR/high CRP exhibited significantly lower cumulative patients' survival rates than both those with high ESR/low CRP and those with low ESR/low CRP. Also, AAV patients with low ESR/high CRP exhibited significantly higher simultaneous BVAS than those with low ESR/low CRP. CONCLUSIONS: Low ESR/high CRP at diagnosis could not only estimate the simultaneous high BVAS but also predict all‐cause mortality during follow‐up in AAV patients.
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spelling pubmed-88411322022-02-22 Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis Park, Pil Gyu Song, Jason Jungsik Park, Yong‐Beom Lee, Sang‐Won J Clin Lab Anal Research Articles BACKGROUND: This study investigated whether the discordance between erythrocyte sedimentation rate (ESR) and C‐reactive protein at diagnosis could estimate the simultaneous clinical and laboratory variables and predict the poor outcomes during follow‐up in patients with antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). METHODS: The medical records of 254 AAV patients were reviewed. Clinical and laboratory and AAV‐specific indices at diagnosis and all‐cause mortality, relapse and end‐stage renal disease during follow‐up were obtained. ESR and CRP levels were categorised as high and low based on the median values. Accordingly, the patients were divided into the following four groups: high ESR/low CRP; low ESR/high CRP; low ESR/low CRP; and high ESR/high CRP. RESULTS: Of the 254 AAV patients, 51 patients exhibited discordance between ESR and CRP. Among the 51 AAV patients, the median age was 59.0 years, and 20 patients were men (29 MPA, 13 GPA and 9 EGPA). Cardiovascular and nervous systemic manifestations were observed more frequently in AAV patients with low ESR/high CRP than in those with high ESR/low CRP. Six patients from the low ESR/high CRP group died. AAV patients with low ESR/high CRP exhibited significantly lower cumulative patients' survival rates than both those with high ESR/low CRP and those with low ESR/low CRP. Also, AAV patients with low ESR/high CRP exhibited significantly higher simultaneous BVAS than those with low ESR/low CRP. CONCLUSIONS: Low ESR/high CRP at diagnosis could not only estimate the simultaneous high BVAS but also predict all‐cause mortality during follow‐up in AAV patients. John Wiley and Sons Inc. 2022-01-08 /pmc/articles/PMC8841132/ /pubmed/34997790 http://dx.doi.org/10.1002/jcla.24237 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Park, Pil Gyu
Song, Jason Jungsik
Park, Yong‐Beom
Lee, Sang‐Won
Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
title Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
title_full Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
title_fullStr Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
title_full_unstemmed Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
title_short Clinical application of low erythrocyte sedimentation rate/high C‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
title_sort clinical application of low erythrocyte sedimentation rate/high c‐reactive protein to antineutrophil cytoplasmic antibody‐associated vasculitis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841132/
https://www.ncbi.nlm.nih.gov/pubmed/34997790
http://dx.doi.org/10.1002/jcla.24237
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