Cargando…

Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population

BACKGROUND: Blood group O has been reported to be a potentially protective factor for Crohn's disease (CD) susceptibility in Caucasian and Korean populations, but a similar conclusion was not found in a Chinese study. The present study investigated the potential association in the Chinese Han p...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jintong, Chen, Huaning, Lin, Yi, Zheng, Weiwei, Wang, Chengdang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841188/
https://www.ncbi.nlm.nih.gov/pubmed/34952990
http://dx.doi.org/10.1002/jcla.24195
_version_ 1784650782014963712
author Chen, Jintong
Chen, Huaning
Lin, Yi
Zheng, Weiwei
Wang, Chengdang
author_facet Chen, Jintong
Chen, Huaning
Lin, Yi
Zheng, Weiwei
Wang, Chengdang
author_sort Chen, Jintong
collection PubMed
description BACKGROUND: Blood group O has been reported to be a potentially protective factor for Crohn's disease (CD) susceptibility in Caucasian and Korean populations, but a similar conclusion was not found in a Chinese study. The present study investigated the potential association in the Chinese Han population. METHODS: We included 275 CD patients, 132 ulcerative colitis (UC) patients and 1201 healthy individuals in this case‐control study. The demographic characteristics and ABO blood group were compared among the three groups. The clinical characteristics and treatment of CD were further investigated according to the blood group distribution. RESULTS: The blood group distribution in CD patients was significantly different from healthy controls, and the frequency of O blood in CD patients was significantly lower compared to healthy controls. After adjusting for age and gender, the non‐O blood groups remained significantly associated with CD susceptibility in propensity score‐adjusted and propensity score‐matched analyses. Compared to CD patients with non‐O blood groups, patients with O blood were at a lower risk of developing penetrating disease, more likely to receive immunosuppressant treatment and less likely to receive biological treatment. CONCLUSION: Our results confirmed that non‐O blood groups were significantly associated with an increased risk of CD in the Chinese Han population.
format Online
Article
Text
id pubmed-8841188
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-88411882022-02-22 Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population Chen, Jintong Chen, Huaning Lin, Yi Zheng, Weiwei Wang, Chengdang J Clin Lab Anal Research Articles BACKGROUND: Blood group O has been reported to be a potentially protective factor for Crohn's disease (CD) susceptibility in Caucasian and Korean populations, but a similar conclusion was not found in a Chinese study. The present study investigated the potential association in the Chinese Han population. METHODS: We included 275 CD patients, 132 ulcerative colitis (UC) patients and 1201 healthy individuals in this case‐control study. The demographic characteristics and ABO blood group were compared among the three groups. The clinical characteristics and treatment of CD were further investigated according to the blood group distribution. RESULTS: The blood group distribution in CD patients was significantly different from healthy controls, and the frequency of O blood in CD patients was significantly lower compared to healthy controls. After adjusting for age and gender, the non‐O blood groups remained significantly associated with CD susceptibility in propensity score‐adjusted and propensity score‐matched analyses. Compared to CD patients with non‐O blood groups, patients with O blood were at a lower risk of developing penetrating disease, more likely to receive immunosuppressant treatment and less likely to receive biological treatment. CONCLUSION: Our results confirmed that non‐O blood groups were significantly associated with an increased risk of CD in the Chinese Han population. John Wiley and Sons Inc. 2021-12-24 /pmc/articles/PMC8841188/ /pubmed/34952990 http://dx.doi.org/10.1002/jcla.24195 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Chen, Jintong
Chen, Huaning
Lin, Yi
Zheng, Weiwei
Wang, Chengdang
Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population
title Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population
title_full Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population
title_fullStr Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population
title_full_unstemmed Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population
title_short Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population
title_sort association between abo blood group and risk of crohn’s disease: a case‐control study in the chinese han population
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841188/
https://www.ncbi.nlm.nih.gov/pubmed/34952990
http://dx.doi.org/10.1002/jcla.24195
work_keys_str_mv AT chenjintong associationbetweenabobloodgroupandriskofcrohnsdiseaseacasecontrolstudyinthechinesehanpopulation
AT chenhuaning associationbetweenabobloodgroupandriskofcrohnsdiseaseacasecontrolstudyinthechinesehanpopulation
AT linyi associationbetweenabobloodgroupandriskofcrohnsdiseaseacasecontrolstudyinthechinesehanpopulation
AT zhengweiwei associationbetweenabobloodgroupandriskofcrohnsdiseaseacasecontrolstudyinthechinesehanpopulation
AT wangchengdang associationbetweenabobloodgroupandriskofcrohnsdiseaseacasecontrolstudyinthechinesehanpopulation