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Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population
BACKGROUND: Blood group O has been reported to be a potentially protective factor for Crohn's disease (CD) susceptibility in Caucasian and Korean populations, but a similar conclusion was not found in a Chinese study. The present study investigated the potential association in the Chinese Han p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841188/ https://www.ncbi.nlm.nih.gov/pubmed/34952990 http://dx.doi.org/10.1002/jcla.24195 |
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author | Chen, Jintong Chen, Huaning Lin, Yi Zheng, Weiwei Wang, Chengdang |
author_facet | Chen, Jintong Chen, Huaning Lin, Yi Zheng, Weiwei Wang, Chengdang |
author_sort | Chen, Jintong |
collection | PubMed |
description | BACKGROUND: Blood group O has been reported to be a potentially protective factor for Crohn's disease (CD) susceptibility in Caucasian and Korean populations, but a similar conclusion was not found in a Chinese study. The present study investigated the potential association in the Chinese Han population. METHODS: We included 275 CD patients, 132 ulcerative colitis (UC) patients and 1201 healthy individuals in this case‐control study. The demographic characteristics and ABO blood group were compared among the three groups. The clinical characteristics and treatment of CD were further investigated according to the blood group distribution. RESULTS: The blood group distribution in CD patients was significantly different from healthy controls, and the frequency of O blood in CD patients was significantly lower compared to healthy controls. After adjusting for age and gender, the non‐O blood groups remained significantly associated with CD susceptibility in propensity score‐adjusted and propensity score‐matched analyses. Compared to CD patients with non‐O blood groups, patients with O blood were at a lower risk of developing penetrating disease, more likely to receive immunosuppressant treatment and less likely to receive biological treatment. CONCLUSION: Our results confirmed that non‐O blood groups were significantly associated with an increased risk of CD in the Chinese Han population. |
format | Online Article Text |
id | pubmed-8841188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88411882022-02-22 Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population Chen, Jintong Chen, Huaning Lin, Yi Zheng, Weiwei Wang, Chengdang J Clin Lab Anal Research Articles BACKGROUND: Blood group O has been reported to be a potentially protective factor for Crohn's disease (CD) susceptibility in Caucasian and Korean populations, but a similar conclusion was not found in a Chinese study. The present study investigated the potential association in the Chinese Han population. METHODS: We included 275 CD patients, 132 ulcerative colitis (UC) patients and 1201 healthy individuals in this case‐control study. The demographic characteristics and ABO blood group were compared among the three groups. The clinical characteristics and treatment of CD were further investigated according to the blood group distribution. RESULTS: The blood group distribution in CD patients was significantly different from healthy controls, and the frequency of O blood in CD patients was significantly lower compared to healthy controls. After adjusting for age and gender, the non‐O blood groups remained significantly associated with CD susceptibility in propensity score‐adjusted and propensity score‐matched analyses. Compared to CD patients with non‐O blood groups, patients with O blood were at a lower risk of developing penetrating disease, more likely to receive immunosuppressant treatment and less likely to receive biological treatment. CONCLUSION: Our results confirmed that non‐O blood groups were significantly associated with an increased risk of CD in the Chinese Han population. John Wiley and Sons Inc. 2021-12-24 /pmc/articles/PMC8841188/ /pubmed/34952990 http://dx.doi.org/10.1002/jcla.24195 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Chen, Jintong Chen, Huaning Lin, Yi Zheng, Weiwei Wang, Chengdang Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population |
title | Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population |
title_full | Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population |
title_fullStr | Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population |
title_full_unstemmed | Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population |
title_short | Association between ABO blood group and risk of Crohn’s disease: A case‐control study in the Chinese Han population |
title_sort | association between abo blood group and risk of crohn’s disease: a case‐control study in the chinese han population |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841188/ https://www.ncbi.nlm.nih.gov/pubmed/34952990 http://dx.doi.org/10.1002/jcla.24195 |
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