CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

OBJECTIVE: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation, downstream effects, and contribution to tumor de...

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Detalles Bibliográficos
Autores principales: Chen, Yihui, Capello, Michela, Rios Perez, Mayrim V., Vykoukal, Jody V., Roife, David, Kang, Ya'an, Prakash, Laura R., Katayama, Hiroyuki, Irajizad, Ehsan, Fleury, Alia, Ferri-Borgogno, Sammy, Baluya, Dodge L., Dennison, Jennifer B., Do, Kim-Anh, Fiehn, Oliver, Maitra, Anirban, Wang, Huamin, Chiao, Paul J., Katz, Matthew H.G., Fleming, Jason B., Hanash, Samir M., Fahrmann, Johannes F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841288/
https://www.ncbi.nlm.nih.gov/pubmed/34971802
http://dx.doi.org/10.1016/j.molmet.2021.101426

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