Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

AIMS: Genome-wide association studies (GWASs) have discovered hundreds of common genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of susceptibility loci into biological mechanisms and targets for drug discovery remains challenging. Intersecting genetic an...

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Detalles Bibliográficos
Autores principales: Slenders, Lotte, Landsmeer, Lennart P L, Cui, Kai, Depuydt, Marie A C, Verwer, Maarten, Mekke, Joost, Timmerman, Nathalie, van den Dungen, Noortje A M, Kuiper, Johan, de Winther, Menno P J, Prange, Koen H M, Ma, Wei Feng, Miller, Clint L, Aherrahrou, Redouane, Civelek, Mete, de Borst, Gert J, de Kleijn, Dominique P V, Asselbergs, Folkert W, den Ruijter, Hester M, Boltjes, Arjan, Pasterkamp, Gerard, van der Laan, Sander W, Mokry, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841481/
https://www.ncbi.nlm.nih.gov/pubmed/35174364
http://dx.doi.org/10.1093/ehjopen/oeab043

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