A comprehensive profile of TCF1(+) progenitor and TCF1(−) terminally exhausted PD-1(+)CD8(+) T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

The heterogeneity of exhausted T cells (Tex) is a critical determinant of immune checkpoint blockade therapy efficacy. However, few studies have explored exhausted T cell subpopulations in human cancers. In the present study, we examined samples from two cohorts of 175 patients with head and neck sq...

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Detalles Bibliográficos
Autores principales: Wang, Dikan, Fang, Juan, Wen, Shuqiong, Li, Qunxing, Wang, Jinming, Yang, Lisa, Dai, Wenxiao, Lu, Huanzi, Guo, Junyi, Shan, Zhongyan, Xie, Wenqiang, Liu, Xiangqi, Wen, Liling, Shen, Jie, Wang, Anxun, Chen, Qianming, Wang, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841504/
https://www.ncbi.nlm.nih.gov/pubmed/35153298
http://dx.doi.org/10.1038/s41368-022-00160-w

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