Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression

Ornithine transcarbamylase deficiency is a rare X-linked genetic urea cycle disorder leading to episodes of acute hyperammonemia, adverse cognitive and neurological effects, hospitalizations, and in some cases death. DTX301, a non-replicating, recombinant self-complimentary adeno-associated virus ve...

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Detalles Bibliográficos
Autores principales: Wang, Lili, Warzecha, Claude C., Kistner, Alexander, Chichester, Jessica A., Bell, Peter, Buza, Elizabeth L., He, Zhenning, Pampena, M. Betina, Couthouis, Julien, Sethi, Sunjay, McKeever, Kathleen, Betts, Michael R., Kakkis, Emil, Wilson, James M., Wadsworth, Samuel, Sullivan, Barbara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841522/
https://www.ncbi.nlm.nih.gov/pubmed/35211641
http://dx.doi.org/10.1016/j.omtm.2022.01.007

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