Uncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia

Rapid removal of glutamate from the sites of glutamate release is an essential step in excitatory synaptic transmission. However, despite many years of research, the molecular mechanisms underlying the intracellular regulation of glutamate transport at tripartite synapses have not been fully uncover...

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Detalles Bibliográficos
Autores principales: Hirschberg, Stefan, Dvorzhak, Anton, Rasooli-Nejad, Seyed M. A., Angelov, Svilen, Kirchner, Marieluise, Mertins, Philipp, Lättig-Tünnemann, Gilla, Harms, Christoph, Schmitz, Dietmar, Grantyn, Rosemarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841566/
https://www.ncbi.nlm.nih.gov/pubmed/35173582
http://dx.doi.org/10.3389/fncel.2021.792652

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