Cargando…

Neuroinflammation and Neutrophils: Modulation by Ouabain

Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na(+)/K(+)-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune respon...

Descripción completa

Detalles Bibliográficos
Autores principales: Leite, Jacqueline Alves, Cavalcante-Silva, Luiz Henrique Agra, Ribeiro, Martina Raissa, de Morais Lima, Geovanni, Scavone, Cristoforo, Rodrigues-Mascarenhas, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841582/
https://www.ncbi.nlm.nih.gov/pubmed/35173621
http://dx.doi.org/10.3389/fphar.2022.824907
_version_ 1784650866440011776
author Leite, Jacqueline Alves
Cavalcante-Silva, Luiz Henrique Agra
Ribeiro, Martina Raissa
de Morais Lima, Geovanni
Scavone, Cristoforo
Rodrigues-Mascarenhas, Sandra
author_facet Leite, Jacqueline Alves
Cavalcante-Silva, Luiz Henrique Agra
Ribeiro, Martina Raissa
de Morais Lima, Geovanni
Scavone, Cristoforo
Rodrigues-Mascarenhas, Sandra
author_sort Leite, Jacqueline Alves
collection PubMed
description Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na(+)/K(+)-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration, and inflammation (peripherally and in the nervous system). Inflammation can occur in response to homeostasis perturbations and is related to the development of many diseases, including immune-mediated diseases and neurodegenerative disorders. Considering the neutrophils role in the general neuroinflammatory response and that these cells can be modulated by cardiac steroids, this work aims to review the possible regulation of neutrophilic neuroinflammation by the cardiac steroid ouabain.
format Online
Article
Text
id pubmed-8841582
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88415822022-02-15 Neuroinflammation and Neutrophils: Modulation by Ouabain Leite, Jacqueline Alves Cavalcante-Silva, Luiz Henrique Agra Ribeiro, Martina Raissa de Morais Lima, Geovanni Scavone, Cristoforo Rodrigues-Mascarenhas, Sandra Front Pharmacol Pharmacology Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na(+)/K(+)-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration, and inflammation (peripherally and in the nervous system). Inflammation can occur in response to homeostasis perturbations and is related to the development of many diseases, including immune-mediated diseases and neurodegenerative disorders. Considering the neutrophils role in the general neuroinflammatory response and that these cells can be modulated by cardiac steroids, this work aims to review the possible regulation of neutrophilic neuroinflammation by the cardiac steroid ouabain. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841582/ /pubmed/35173621 http://dx.doi.org/10.3389/fphar.2022.824907 Text en Copyright © 2022 Leite, Cavalcante-Silva, Ribeiro, de Morais Lima, Scavone and Rodrigues-Mascarenhas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Leite, Jacqueline Alves
Cavalcante-Silva, Luiz Henrique Agra
Ribeiro, Martina Raissa
de Morais Lima, Geovanni
Scavone, Cristoforo
Rodrigues-Mascarenhas, Sandra
Neuroinflammation and Neutrophils: Modulation by Ouabain
title Neuroinflammation and Neutrophils: Modulation by Ouabain
title_full Neuroinflammation and Neutrophils: Modulation by Ouabain
title_fullStr Neuroinflammation and Neutrophils: Modulation by Ouabain
title_full_unstemmed Neuroinflammation and Neutrophils: Modulation by Ouabain
title_short Neuroinflammation and Neutrophils: Modulation by Ouabain
title_sort neuroinflammation and neutrophils: modulation by ouabain
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841582/
https://www.ncbi.nlm.nih.gov/pubmed/35173621
http://dx.doi.org/10.3389/fphar.2022.824907
work_keys_str_mv AT leitejacquelinealves neuroinflammationandneutrophilsmodulationbyouabain
AT cavalcantesilvaluizhenriqueagra neuroinflammationandneutrophilsmodulationbyouabain
AT ribeiromartinaraissa neuroinflammationandneutrophilsmodulationbyouabain
AT demoraislimageovanni neuroinflammationandneutrophilsmodulationbyouabain
AT scavonecristoforo neuroinflammationandneutrophilsmodulationbyouabain
AT rodriguesmascarenhassandra neuroinflammationandneutrophilsmodulationbyouabain