Cargando…
Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer
Ovarian cancer (OV) is an epithelial malignancy that intrigues people for its high mortality and lack of efficient treatment. Chemokine-like factor (CKLF)–like MARVEL transmembrane domain containing 6 (CMTM6) can be observed in various cancers, but its part in OV remains little known. Hence, the pro...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841687/ https://www.ncbi.nlm.nih.gov/pubmed/35174213 http://dx.doi.org/10.3389/fmolb.2022.769032 |
_version_ | 1784650890166140928 |
---|---|
author | Yin, Bo Ding, Jianyi Hu, Haoran Yang, Meiqin Huang, Baoyou Dong, Wei Li, Fang Han, Lingfei |
author_facet | Yin, Bo Ding, Jianyi Hu, Haoran Yang, Meiqin Huang, Baoyou Dong, Wei Li, Fang Han, Lingfei |
author_sort | Yin, Bo |
collection | PubMed |
description | Ovarian cancer (OV) is an epithelial malignancy that intrigues people for its high mortality and lack of efficient treatment. Chemokine-like factor (CKLF)–like MARVEL transmembrane domain containing 6 (CMTM6) can be observed in various cancers, but its part in OV remains little known. Hence, the prognostic value and underlying mechanism of CMTM6 in OV were preliminarily evaluated. Here, we determined that CMTM6 expression was higher than that in normal controls. However, the upregulation of CMTM6 was associated with better prognosis. GSEA results suggested that CMTM6 is involved in the immune-related and metabolism-related pathways. GO/KEGG analysis of CMTM6 coexpressed genes was performed to survey the possible regulatory roles of CMTM6 in OV. Subsequently, CMTM6 expression was positively correlated with the infiltration levels of immune cells and the expression of diverse immune cell marker sets. Importantly, CMTM6 may influence prognosis partially by regulating immune infiltration in OV. Last, copy number variations (CNVs) and DNA methylation might prompt the abnormal CMTM6 expression in OV. In conclusion, CMTM6 can serve as a novel prognostic biomarker in patients with OV. |
format | Online Article Text |
id | pubmed-8841687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88416872022-02-15 Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer Yin, Bo Ding, Jianyi Hu, Haoran Yang, Meiqin Huang, Baoyou Dong, Wei Li, Fang Han, Lingfei Front Mol Biosci Molecular Biosciences Ovarian cancer (OV) is an epithelial malignancy that intrigues people for its high mortality and lack of efficient treatment. Chemokine-like factor (CKLF)–like MARVEL transmembrane domain containing 6 (CMTM6) can be observed in various cancers, but its part in OV remains little known. Hence, the prognostic value and underlying mechanism of CMTM6 in OV were preliminarily evaluated. Here, we determined that CMTM6 expression was higher than that in normal controls. However, the upregulation of CMTM6 was associated with better prognosis. GSEA results suggested that CMTM6 is involved in the immune-related and metabolism-related pathways. GO/KEGG analysis of CMTM6 coexpressed genes was performed to survey the possible regulatory roles of CMTM6 in OV. Subsequently, CMTM6 expression was positively correlated with the infiltration levels of immune cells and the expression of diverse immune cell marker sets. Importantly, CMTM6 may influence prognosis partially by regulating immune infiltration in OV. Last, copy number variations (CNVs) and DNA methylation might prompt the abnormal CMTM6 expression in OV. In conclusion, CMTM6 can serve as a novel prognostic biomarker in patients with OV. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841687/ /pubmed/35174213 http://dx.doi.org/10.3389/fmolb.2022.769032 Text en Copyright © 2022 Yin, Ding, Hu, Yang, Huang, Dong, Li and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Yin, Bo Ding, Jianyi Hu, Haoran Yang, Meiqin Huang, Baoyou Dong, Wei Li, Fang Han, Lingfei Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer |
title | Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer |
title_full | Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer |
title_fullStr | Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer |
title_full_unstemmed | Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer |
title_short | Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer |
title_sort | overexpressed cmtm6 improves prognosis and associated with immune infiltrates of ovarian cancer |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841687/ https://www.ncbi.nlm.nih.gov/pubmed/35174213 http://dx.doi.org/10.3389/fmolb.2022.769032 |
work_keys_str_mv | AT yinbo overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer AT dingjianyi overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer AT huhaoran overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer AT yangmeiqin overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer AT huangbaoyou overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer AT dongwei overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer AT lifang overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer AT hanlingfei overexpressedcmtm6improvesprognosisandassociatedwithimmuneinfiltratesofovariancancer |