Lirilumab and Avelumab Enhance Anti-HPV+ Cervical Cancer Activity of Natural Killer Cells via Vav1-Dependent NF-κB Disinhibition

BACKGROUND: We investigated the efficacy and mechanism of the anti-KIR immunotherapy lirilumab and anti-PD-L1 immunotherapy avelumab on natural killer (NK) cell activity against HPV+ cervical cancer. METHODS: NK cell-mediated lysis of autologous biopsy-derived malignant cervical squamous cells and n...

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Detalles Bibliográficos
Autores principales: Liu, Hongli, Zhou, Sihui, Liu, Jing, Chen, Fuliang, Zhang, Yuan, Liu, Mengjun, Min, Shengping, Wang, Hongtao, Wang, Xiaojing, Wu, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841689/
https://www.ncbi.nlm.nih.gov/pubmed/35174079
http://dx.doi.org/10.3389/fonc.2022.747482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841689/
https://www.ncbi.nlm.nih.gov/pubmed/35174079
http://dx.doi.org/10.3389/fonc.2022.747482

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