Cargando…

Lirilumab and Avelumab Enhance Anti-HPV+ Cervical Cancer Activity of Natural Killer Cells via Vav1-Dependent NF-κB Disinhibition

BACKGROUND: We investigated the efficacy and mechanism of the anti-KIR immunotherapy lirilumab and anti-PD-L1 immunotherapy avelumab on natural killer (NK) cell activity against HPV+ cervical cancer. METHODS: NK cell-mediated lysis of autologous biopsy-derived malignant cervical squamous cells and n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hongli, Zhou, Sihui, Liu, Jing, Chen, Fuliang, Zhang, Yuan, Liu, Mengjun, Min, Shengping, Wang, Hongtao, Wang, Xiaojing, Wu, Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841689/ https://www.ncbi.nlm.nih.gov/pubmed/35174079 http://dx.doi.org/10.3389/fonc.2022.747482

Ejemplares similares

NF-κB disinhibition contributes to dendrite defects in fly models of neurodegenerative diseases
por: Han, Myeong Hoon, et al.
Publicado: (2020)

Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck
por: Hanna, Glenn J., et al.
Publicado: (2022)

VAV1 and BAFF, via NFκB pathway, are genetic risk factors for myasthenia gravis
por: Avidan, Nili, et al.
Publicado: (2014)

A phase 1 study of lirilumab (antibody against killer immunoglobulin-like receptor antibody KIR2D; IPH2102) in patients with solid tumors and hematologic malignancies
por: Vey, Norbert, et al.
Publicado: (2018)

Functional Dichotomy in Natural Killer Cell Signaling: Vav1-Dependent and -Independent Mechanisms
por: Colucci, Francesco, et al.
Publicado: (2001)

Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors
por: Perretta-Tejedor, Nuria, et al.
Publicado: (2017)

Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence
por: Wang, Xiaojing, et al.
Publicado: (2019)

Corrigendum: Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors
por: Perretta-Tejedor, Nuria, et al.
Publicado: (2018)

Anti-tumoral efficacy of therapeutic human anti-KIR antibody (Lirilumab/BMS-986015/IPH2102) in a preclinical xenograft tumor model
por: Sola, Caroline, et al.
Publicado: (2013)

VAV2 and VAV3 as Candidate Disease Genes for Spontaneous Glaucoma in Mice and Humans
por: Fujikawa, Keiko, et al.
Publicado: (2010)

Avelumab in newly diagnosed glioblastoma
por: Jacques, Francois H, et al.
Publicado: (2021)

Disinhibition Bursting of Dopaminergic Neurons
por: Lobb, Collin J., et al.
Publicado: (2011)

Saccadic Disinhibition on the Saccade Trace
por: Yan, Hongmei, et al.
Publicado: (2011)

Stimulus-induced Epileptic Spike-Wave Discharges in Thalamocortical Model with Disinhibition
por: Fan, Denggui, et al.
Publicado: (2016)

VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance
por: Liu, Weiling, et al.
Publicado: (2021)

Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
por: Li, Si, et al.
Publicado: (2021)

Vav2 is required for cell spreading
por: Marignani, Paola A., et al.
Publicado: (2001)

Vav Proteins' Role in Skin Cancer
por: Mejia, Robin
Publicado: (2013)

Avelumab demonstrates promise in advanced NSCLC
por: Marciscano, Ariel E., et al.
Publicado: (2017)

Evaluation of the potential for QTc prolongation with avelumab
por: Vugmeyster, Yulia, et al.
Publicado: (2019)

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
por: Lorenzo-Martín, L. Francisco, et al.
Publicado: (2022)

NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer
por: Schrank, Travis P., et al.
Publicado: (2022)

Alcohol Disinhibition of Behaviors in C. elegans
por: Topper, Stephen M., et al.
Publicado: (2014)

Disinhibition, an emerging pharmacology of learning and memory
por: Möhler, Hanns, et al.
Publicado: (2017)

Cerebellar circuits for disinhibition and synchronous inhibition
por: Lackey, Elizabeth P., et al.
Publicado: (2023)

Vav1 Phosphorylation Is Induced by β2 Integrin Engagement on Natural Killer Cells Upstream of Actin Cytoskeleton and Lipid Raft Reorganization
por: Riteau, Béatrice, et al.
Publicado: (2003)

Vav Regulates Peptide-specific Apoptosis in Thymocytes
por: Kong, Young-Yun, et al.
Publicado: (1998)

The Vav GEF Family: An Evolutionary and Functional Perspective
por: Rodríguez-Fdez, Sonia, et al.
Publicado: (2019)

Induction of natural killer antibody-dependent cell cytotoxicity and of clinical activity of cetuximab plus avelumab in non-small cell lung cancer
por: Fasano, Morena, et al.
Publicado: (2020)

Immunotherapy in Merkel cell carcinoma: role of Avelumab
por: Palla, Amruth R, et al.
Publicado: (2018)

The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops
por: Menacho-Márquez, Mauricio, et al.
Publicado: (2013)

Vav2 is a novel APP-interacting protein that regulates APP protein level
por: Zhang, Youjia, et al.
Publicado: (2022)

Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward
por: Jiang, Changyou, et al.
Publicado: (2019)

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific
por: Ormond, Jake, et al.
Publicado: (2011)

Enriching the environment to disinhibit the brain and improve cognition
por: Maffei, Arianna
Publicado: (2012)

Motor tics evoked by striatal disinhibition in the rat
por: Bronfeld, Maya, et al.
Publicado: (2013)

Impulsive, Disinhibited Behavior—Dining in a Restaurant
por: Hamdy, Ronald C., et al.
Publicado: (2018)

Generation of Sharp Wave-Ripple Events by Disinhibition
por: Evangelista, Roberta, et al.
Publicado: (2020)

Striatonigrostriatal circuit architecture for disinhibition of dopamine signaling
por: Ambrosi, Priscilla, et al.
Publicado: (2022)

Vav1 Is a Component of Transcriptionally Active Complexes
por: Houlard, Martin, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_qhoghflhpdeir5jme8eltrdbv7