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Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF?
AIM: To evaluate the effect of non-invasive positive pressure ventilation (NIPPV) on (1) metabolic, ventilatory, and hemodynamic responses; and (2) cerebral (Cox), respiratory, and peripheral oxygenation when compared with SHAM ventilation during the high-intensity exercise in patients with coexisti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841720/ https://www.ncbi.nlm.nih.gov/pubmed/35174218 http://dx.doi.org/10.3389/fcvm.2021.772650 |
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author | Goulart, Cássia da Luz Caruso, Flávia Rossi de Araújo, Adriana Sanches Garcia de Moura, Sílvia Cristina Garcia Catai, Aparecida Maria Agostoni, Piergiuseppe Mendes, Renata Gonçalves Arena, Ross Borghi-Silva, Audrey |
author_facet | Goulart, Cássia da Luz Caruso, Flávia Rossi de Araújo, Adriana Sanches Garcia de Moura, Sílvia Cristina Garcia Catai, Aparecida Maria Agostoni, Piergiuseppe Mendes, Renata Gonçalves Arena, Ross Borghi-Silva, Audrey |
author_sort | Goulart, Cássia da Luz |
collection | PubMed |
description | AIM: To evaluate the effect of non-invasive positive pressure ventilation (NIPPV) on (1) metabolic, ventilatory, and hemodynamic responses; and (2) cerebral (Cox), respiratory, and peripheral oxygenation when compared with SHAM ventilation during the high-intensity exercise in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF). METHODS AND RESULTS: On separate days, patients performed incremental cardiopulmonary exercise testing and two constant-work rate tests receiving NIPPV or controlled ventilation (SHAM) (the bilevel mode—Astral 150) in random order until the limit of tolerance (Tlim). During exercise, oxyhemoglobin (OxyHb+Mb) and deoxyhemoglobin (DeoxyHb+Mb) were assessed using near-infrared spectroscopy (Oxymon, Artinis Medical Systems, Einsteinweg, The Netherlands). NIPPV associated with high-intensity exercise caused a significant increase in exercise tolerance, peak oxygen consumption ([Formula: see text] in mlO(2)·kg(−1)·min(−1)), minute ventilation peak ([Formula: see text] in ml/min), peak peripheral oxygen saturation (SpO(2), %), and lactate/tlim (mmol/s) when compared with SHAM ventilation. In cerebral, respiratory, and peripheral muscles, NIPPV resulted in a lower drop in OxyHb+Mb (p < 0.05) and an improved deoxygenation response DeoxyHb+Mb (p < 0.05) from the half of the test (60% of Tlim) when compared with SHAM ventilation. CONCLUSION: Non-invasive positive pressure ventilation during constant work-rate exercise led to providing the respiratory muscle unloading with greater oxygen supply to the peripheral muscles, reducing muscle fatigue, and sustaining longer exercise time in patients with COPD-HF. |
format | Online Article Text |
id | pubmed-8841720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88417202022-02-15 Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF? Goulart, Cássia da Luz Caruso, Flávia Rossi de Araújo, Adriana Sanches Garcia de Moura, Sílvia Cristina Garcia Catai, Aparecida Maria Agostoni, Piergiuseppe Mendes, Renata Gonçalves Arena, Ross Borghi-Silva, Audrey Front Cardiovasc Med Cardiovascular Medicine AIM: To evaluate the effect of non-invasive positive pressure ventilation (NIPPV) on (1) metabolic, ventilatory, and hemodynamic responses; and (2) cerebral (Cox), respiratory, and peripheral oxygenation when compared with SHAM ventilation during the high-intensity exercise in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF). METHODS AND RESULTS: On separate days, patients performed incremental cardiopulmonary exercise testing and two constant-work rate tests receiving NIPPV or controlled ventilation (SHAM) (the bilevel mode—Astral 150) in random order until the limit of tolerance (Tlim). During exercise, oxyhemoglobin (OxyHb+Mb) and deoxyhemoglobin (DeoxyHb+Mb) were assessed using near-infrared spectroscopy (Oxymon, Artinis Medical Systems, Einsteinweg, The Netherlands). NIPPV associated with high-intensity exercise caused a significant increase in exercise tolerance, peak oxygen consumption ([Formula: see text] in mlO(2)·kg(−1)·min(−1)), minute ventilation peak ([Formula: see text] in ml/min), peak peripheral oxygen saturation (SpO(2), %), and lactate/tlim (mmol/s) when compared with SHAM ventilation. In cerebral, respiratory, and peripheral muscles, NIPPV resulted in a lower drop in OxyHb+Mb (p < 0.05) and an improved deoxygenation response DeoxyHb+Mb (p < 0.05) from the half of the test (60% of Tlim) when compared with SHAM ventilation. CONCLUSION: Non-invasive positive pressure ventilation during constant work-rate exercise led to providing the respiratory muscle unloading with greater oxygen supply to the peripheral muscles, reducing muscle fatigue, and sustaining longer exercise time in patients with COPD-HF. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841720/ /pubmed/35174218 http://dx.doi.org/10.3389/fcvm.2021.772650 Text en Copyright © 2022 Goulart, Caruso, de Araújo, Moura, Catai, Agostoni, Mendes, Arena and Borghi-Silva. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Goulart, Cássia da Luz Caruso, Flávia Rossi de Araújo, Adriana Sanches Garcia de Moura, Sílvia Cristina Garcia Catai, Aparecida Maria Agostoni, Piergiuseppe Mendes, Renata Gonçalves Arena, Ross Borghi-Silva, Audrey Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF? |
title | Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF? |
title_full | Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF? |
title_fullStr | Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF? |
title_full_unstemmed | Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF? |
title_short | Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF? |
title_sort | can non-invasive ventilation modulate cerebral, respiratory, and peripheral muscle oxygenation during high-intensity exercise in patients with copd-hf? |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841720/ https://www.ncbi.nlm.nih.gov/pubmed/35174218 http://dx.doi.org/10.3389/fcvm.2021.772650 |
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