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Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tracts and a model for the targeted therapy of solid tumors because of the oncogenic driver mutations in KIT and PDGDRA genes, which could be effectively inhibited by the very first targeted agent, ima...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841737/ https://www.ncbi.nlm.nih.gov/pubmed/35174150 http://dx.doi.org/10.3389/fcell.2022.808591 |
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author | Li, Jiehan Guo, Shuning Sun, Zhenqiang Fu, Yang |
author_facet | Li, Jiehan Guo, Shuning Sun, Zhenqiang Fu, Yang |
author_sort | Li, Jiehan |
collection | PubMed |
description | Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tracts and a model for the targeted therapy of solid tumors because of the oncogenic driver mutations in KIT and PDGDRA genes, which could be effectively inhibited by the very first targeted agent, imatinib mesylate. Most of the GIST patients could benefit a lot from the targeted treatment of this receptor tyrosine kinase inhibitor. However, more than 50% of the patients developed resistance within 2 years after imatinib administration, limiting the long-term effect of imatinib. Noncoding RNAs (ncRNAs), the non-protein coding transcripts of human, were demonstrated to play pivotal roles in the resistance of various chemotherapy drugs. In this review, we summarized the mechanisms of how ncRNAs functioning on the drug resistance in GIST. During the drug resistance of GIST, there were five regulating mechanisms where the functions of ncRNAs concentrated: oxidative phosphorylation, autophagy, apoptosis, drug target changes, and some signaling pathways. Also, these effects of ncRNAs in drug resistance were divided into two aspects. How ncRNAs regulate drug resistance in GIST was further summarized according to ncRNA types, different drugs and categories of resistance. Moreover, clinical applications of these ncRNAs in GIST chemotherapies concentrated on the prognostic biomarkers and novel therapeutic targets. |
format | Online Article Text |
id | pubmed-8841737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88417372022-02-15 Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor Li, Jiehan Guo, Shuning Sun, Zhenqiang Fu, Yang Front Cell Dev Biol Cell and Developmental Biology Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tracts and a model for the targeted therapy of solid tumors because of the oncogenic driver mutations in KIT and PDGDRA genes, which could be effectively inhibited by the very first targeted agent, imatinib mesylate. Most of the GIST patients could benefit a lot from the targeted treatment of this receptor tyrosine kinase inhibitor. However, more than 50% of the patients developed resistance within 2 years after imatinib administration, limiting the long-term effect of imatinib. Noncoding RNAs (ncRNAs), the non-protein coding transcripts of human, were demonstrated to play pivotal roles in the resistance of various chemotherapy drugs. In this review, we summarized the mechanisms of how ncRNAs functioning on the drug resistance in GIST. During the drug resistance of GIST, there were five regulating mechanisms where the functions of ncRNAs concentrated: oxidative phosphorylation, autophagy, apoptosis, drug target changes, and some signaling pathways. Also, these effects of ncRNAs in drug resistance were divided into two aspects. How ncRNAs regulate drug resistance in GIST was further summarized according to ncRNA types, different drugs and categories of resistance. Moreover, clinical applications of these ncRNAs in GIST chemotherapies concentrated on the prognostic biomarkers and novel therapeutic targets. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841737/ /pubmed/35174150 http://dx.doi.org/10.3389/fcell.2022.808591 Text en Copyright © 2022 Li, Guo, Sun and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Li, Jiehan Guo, Shuning Sun, Zhenqiang Fu, Yang Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor |
title | Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor |
title_full | Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor |
title_fullStr | Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor |
title_full_unstemmed | Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor |
title_short | Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor |
title_sort | noncoding rnas in drug resistance of gastrointestinal stromal tumor |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841737/ https://www.ncbi.nlm.nih.gov/pubmed/35174150 http://dx.doi.org/10.3389/fcell.2022.808591 |
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