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Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy

Ferroptosis is an evolutionarily conserved form of regulated cell death triggered by iron-dependent phospholipid peroxidation. Ferroptosis contributes to the maintenance of tissue homeostasis under physiological conditions while its aberration is tightly connected with lots of pathophysiological pro...

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Autores principales: Pei, Yanzi, Qian, Yujie, Wang, Hao, Tan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841808/
https://www.ncbi.nlm.nih.gov/pubmed/35174081
http://dx.doi.org/10.3389/fonc.2022.771870
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author Pei, Yanzi
Qian, Yujie
Wang, Hao
Tan, Li
author_facet Pei, Yanzi
Qian, Yujie
Wang, Hao
Tan, Li
author_sort Pei, Yanzi
collection PubMed
description Ferroptosis is an evolutionarily conserved form of regulated cell death triggered by iron-dependent phospholipid peroxidation. Ferroptosis contributes to the maintenance of tissue homeostasis under physiological conditions while its aberration is tightly connected with lots of pathophysiological processes such as acute tissue injury, chronic degenerative disease, and tumorigenesis. Epigenetic regulation controls chromatin structure and gene expression by writing/reading/erasing the covalent modifications on DNA, histone, and RNA, without altering the DNA sequence. Accumulating evidences suggest that epigenetic regulation is involved in the determination of cellular vulnerability to ferroptosis. Here, we summarize the recent advances on the epigenetic mechanisms that control the expression of ferroptosis-associated genes and thereby the ferroptosis process. Moreover, the potential value of epigenetic drugs in targeting or synergizing ferroptosis during cancer therapy is also discussed.
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spelling pubmed-88418082022-02-15 Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy Pei, Yanzi Qian, Yujie Wang, Hao Tan, Li Front Oncol Oncology Ferroptosis is an evolutionarily conserved form of regulated cell death triggered by iron-dependent phospholipid peroxidation. Ferroptosis contributes to the maintenance of tissue homeostasis under physiological conditions while its aberration is tightly connected with lots of pathophysiological processes such as acute tissue injury, chronic degenerative disease, and tumorigenesis. Epigenetic regulation controls chromatin structure and gene expression by writing/reading/erasing the covalent modifications on DNA, histone, and RNA, without altering the DNA sequence. Accumulating evidences suggest that epigenetic regulation is involved in the determination of cellular vulnerability to ferroptosis. Here, we summarize the recent advances on the epigenetic mechanisms that control the expression of ferroptosis-associated genes and thereby the ferroptosis process. Moreover, the potential value of epigenetic drugs in targeting or synergizing ferroptosis during cancer therapy is also discussed. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841808/ /pubmed/35174081 http://dx.doi.org/10.3389/fonc.2022.771870 Text en Copyright © 2022 Pei, Qian, Wang and Tan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Pei, Yanzi
Qian, Yujie
Wang, Hao
Tan, Li
Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy
title Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy
title_full Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy
title_fullStr Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy
title_full_unstemmed Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy
title_short Epigenetic Regulation of Ferroptosis-Associated Genes and Its Implication in Cancer Therapy
title_sort epigenetic regulation of ferroptosis-associated genes and its implication in cancer therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841808/
https://www.ncbi.nlm.nih.gov/pubmed/35174081
http://dx.doi.org/10.3389/fonc.2022.771870
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