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Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development

Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance mechanisms in mice in response to chronic noise exposure. C5...

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Autores principales: Frenis, Katie, Kalinovic, Sanela, Ernst, Benjamin P., Kvandova, Miroslava, Al Zuabi, Ahmad, Kuntic, Marin, Oelze, Matthias, Stamm, Paul, Bayo Jimenez, Maria Teresa, Kij, Agnieszka, Keppeler, Karin, Klein, Veronique, Strohm, Lea, Ubbens, Henning, Daub, Steffen, Hahad, Omar, Kröller-Schön, Swenja, Schmeisser, Michael J., Chlopicki, Stefan, Eckrich, Jonas, Strieth, Sebastian, Daiber, Andreas, Steven, Sebastian, Münzel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841864/
https://www.ncbi.nlm.nih.gov/pubmed/35174211
http://dx.doi.org/10.3389/fmolb.2021.814921
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author Frenis, Katie
Kalinovic, Sanela
Ernst, Benjamin P.
Kvandova, Miroslava
Al Zuabi, Ahmad
Kuntic, Marin
Oelze, Matthias
Stamm, Paul
Bayo Jimenez, Maria Teresa
Kij, Agnieszka
Keppeler, Karin
Klein, Veronique
Strohm, Lea
Ubbens, Henning
Daub, Steffen
Hahad, Omar
Kröller-Schön, Swenja
Schmeisser, Michael J.
Chlopicki, Stefan
Eckrich, Jonas
Strieth, Sebastian
Daiber, Andreas
Steven, Sebastian
Münzel, Thomas
author_facet Frenis, Katie
Kalinovic, Sanela
Ernst, Benjamin P.
Kvandova, Miroslava
Al Zuabi, Ahmad
Kuntic, Marin
Oelze, Matthias
Stamm, Paul
Bayo Jimenez, Maria Teresa
Kij, Agnieszka
Keppeler, Karin
Klein, Veronique
Strohm, Lea
Ubbens, Henning
Daub, Steffen
Hahad, Omar
Kröller-Schön, Swenja
Schmeisser, Michael J.
Chlopicki, Stefan
Eckrich, Jonas
Strieth, Sebastian
Daiber, Andreas
Steven, Sebastian
Münzel, Thomas
author_sort Frenis, Katie
collection PubMed
description Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance mechanisms in mice in response to chronic noise exposure. C57BL/6J mice were exposed to aircraft noise for 0, 4, 7, 14 and 28d at a mean sound pressure level of 72 dB(A) and peak levels of 85 dB(A). Chronic aircraft noise exposure up to 28d caused persistent endothelial dysfunction and elevation of blood pressure. Likewise, reactive oxygen species (ROS) formation as determined by dihydroethidium (DHE) staining and HPLC-based measurement of superoxide formation in the aorta/heart/brain was time-dependently increased by noise. Oxidative burst in the whole blood showed a maximum at 4d or 7d of noise exposure. Increased superoxide formation in the brain was mirrored by a downregulation of neuronal nitric oxide synthase (Nos3) and transcription factor Foxo3 genes, whereas Vcam1 mRNA, a marker for inflammation was upregulated in all noise exposure groups. Induction of a pronounced hearing loss in the mice was excluded by auditory brainstem response audiometry. Endothelial dysfunction and inflammation were present during the entire 28d of aircraft noise exposure. ROS formation gradually increases with ongoing exposure without significant adaptation or tolerance in mice in response to chronic noise stress at moderate levels. These data further illustrate health side effects of long-term noise exposure and further strengthen a consequent implementation of the WHO noise guidelines in order to prevent the development of noise-related future cardiovascular disease.
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spelling pubmed-88418642022-02-15 Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development Frenis, Katie Kalinovic, Sanela Ernst, Benjamin P. Kvandova, Miroslava Al Zuabi, Ahmad Kuntic, Marin Oelze, Matthias Stamm, Paul Bayo Jimenez, Maria Teresa Kij, Agnieszka Keppeler, Karin Klein, Veronique Strohm, Lea Ubbens, Henning Daub, Steffen Hahad, Omar Kröller-Schön, Swenja Schmeisser, Michael J. Chlopicki, Stefan Eckrich, Jonas Strieth, Sebastian Daiber, Andreas Steven, Sebastian Münzel, Thomas Front Mol Biosci Molecular Biosciences Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance mechanisms in mice in response to chronic noise exposure. C57BL/6J mice were exposed to aircraft noise for 0, 4, 7, 14 and 28d at a mean sound pressure level of 72 dB(A) and peak levels of 85 dB(A). Chronic aircraft noise exposure up to 28d caused persistent endothelial dysfunction and elevation of blood pressure. Likewise, reactive oxygen species (ROS) formation as determined by dihydroethidium (DHE) staining and HPLC-based measurement of superoxide formation in the aorta/heart/brain was time-dependently increased by noise. Oxidative burst in the whole blood showed a maximum at 4d or 7d of noise exposure. Increased superoxide formation in the brain was mirrored by a downregulation of neuronal nitric oxide synthase (Nos3) and transcription factor Foxo3 genes, whereas Vcam1 mRNA, a marker for inflammation was upregulated in all noise exposure groups. Induction of a pronounced hearing loss in the mice was excluded by auditory brainstem response audiometry. Endothelial dysfunction and inflammation were present during the entire 28d of aircraft noise exposure. ROS formation gradually increases with ongoing exposure without significant adaptation or tolerance in mice in response to chronic noise stress at moderate levels. These data further illustrate health side effects of long-term noise exposure and further strengthen a consequent implementation of the WHO noise guidelines in order to prevent the development of noise-related future cardiovascular disease. Frontiers Media S.A. 2022-01-31 /pmc/articles/PMC8841864/ /pubmed/35174211 http://dx.doi.org/10.3389/fmolb.2021.814921 Text en Copyright © 2022 Frenis, Kalinovic, Ernst, Kvandova, Al Zuabi, Kuntic, Oelze, Stamm, Bayo Jimenez, Kij, Keppeler, Klein, Strohm, Ubbens, Daub, Hahad, Kröller-Schön, Schmeisser, Chlopicki, Eckrich, Strieth, Daiber, Steven and Münzel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Frenis, Katie
Kalinovic, Sanela
Ernst, Benjamin P.
Kvandova, Miroslava
Al Zuabi, Ahmad
Kuntic, Marin
Oelze, Matthias
Stamm, Paul
Bayo Jimenez, Maria Teresa
Kij, Agnieszka
Keppeler, Karin
Klein, Veronique
Strohm, Lea
Ubbens, Henning
Daub, Steffen
Hahad, Omar
Kröller-Schön, Swenja
Schmeisser, Michael J.
Chlopicki, Stefan
Eckrich, Jonas
Strieth, Sebastian
Daiber, Andreas
Steven, Sebastian
Münzel, Thomas
Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development
title Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development
title_full Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development
title_fullStr Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development
title_full_unstemmed Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development
title_short Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development
title_sort long-term effects of aircraft noise exposure on vascular oxidative stress, endothelial function and blood pressure: no evidence for adaptation or tolerance development
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841864/
https://www.ncbi.nlm.nih.gov/pubmed/35174211
http://dx.doi.org/10.3389/fmolb.2021.814921
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