A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics

Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [(15)O] H(2)O/ CO(2) and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However...

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Detalles Bibliográficos
Autores principales: Kameyama, Masashi, Momose, Toshimitsu, Ishibashi, Kenji, Ishii, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841875/
https://www.ncbi.nlm.nih.gov/pubmed/35173665
http://dx.doi.org/10.3389/fneur.2021.765463
Descripción
Sumario:Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [(15)O] H(2)O/ CO(2) and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However, this formula has not been confirmed to be proportionate to CPP. We have developed a new index for CPP using the Poiseuille equation based on a simple model. Our model suggests that CBF/CBV(2) is proportionate to CPP and that it is mathematically a more accurate index than CBF/CBV. This new index needs experimental validation in the future.

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